What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Captopril + Zinc pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·a caution·Moderate evidence

Captopril + Zinc

Q: Can I take Captopril and Zinc together?

Possibly, but with caution. Captopril and Zinc have a documented caution-tier interaction. The sulfhydryl group of captopril chelates zinc and increases urinary zinc excretion, and long-term ACE inhibitor therapy has been associated with reduced zinc status in some patients. Low zinc has been linked to taste disturbances, a recognized captopril side effect. Conversely, when supplementing, zinc and captopril taken together may chelate in the gut and modestly reduce absorption of each.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Moderate evidence

The sulfhydryl group of captopril chelates zinc and increases urinary zinc excretion, and long-term ACE inhibitor therapy has been associated with reduced zinc status in some patients. Low zinc has been linked to taste disturbances, a recognized captopril side effect. Conversely, when supplementing, zinc and captopril taken together may chelate in the gut and modestly reduce absorption of each.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Captopril and Zinc

Pair type

Caution

Evidence

Moderate

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

CautionModerate evidence

What is happening. The sulfhydryl group of captopril chelates zinc and increases urinary zinc excretion, and long-term ACE inhibitor therapy has been associated with reduced zinc status in some patients. Low zinc has been linked to taste disturbances, a recognized captopril side effect. Conversely, when supplementing, zinc and captopril taken together may chelate in the gut and modestly reduce absorption of each.

Mechanism. Captopril's thiol moiety binds zinc, forming a chelate that increases renal zinc loss over time and can lower body zinc stores; this depletion mechanism is distinct from a same-dose absorption effect.

Recommendation. No supplement is required for most patients. If taste disturbance or signs of zinc deficiency develop during long-term captopril therapy, discuss zinc status with a clinician. If supplementing zinc, separating it from captopril by about 2 hours may limit gut chelation.

Stack Score

How it moves the number.

Effect on the composite score

If both Captopril and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Golik A, et al. Zinc metabolism in patients treated with captopril versus enalapril. Metabolism. 1990.Needs sourceNo link
2Suliburska J, et al. The influence of antihypertensive drugs on mineral status in hypertensive patients. European Review for Medical and Pharmacological Sciences. 2014.Needs sourceNo link

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