NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Calcium and Zinc: what the published research says

PubMed indexes 8 records that name Calcium and Zinc together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium and Zinc. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Calcium and Zinc.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Plasma membrane-associated calcium signaling modulates zinc homeostasis in Arabidopsis.

Science bulletin · 2025 · PMID 39979205

“Collectively, our findings identify a plasma membrane-associated calcium signaling pathway that regulates Zn homeostasis in Arabidopsis thaliana. This pathway represents a promising target for molecular breeding approaches aimed at developing crops with enhanced tolerance to Zn deficiency.”

Fang et al. · From the abstract

Names both Calcium and Zinc in its title.

A Zinc- and Calcium-Rich Lysosomal Nanoreactor Rescues Monocyte/Macrophage Dysfunction under Sepsis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023 · PMID 36596693

Human subjects

“They also release calcium and zinc ions into monocyte/macrophage lysosomes to promote the Pha and degradation of bacteria. Taken together, these results suggest that Alpha-MOFs rescue monocytes/macrophages dysfunction and effectively improve their survival rate during sepsis.”

Zhao et al. · From the abstract

Names both Calcium and Zinc in its title.

Effects of a calcium/vitamin D/Zinc combination on anti-osteoporosis in ovariectomized rats.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023 · PMID 36773556

Human subjects

“The combined supplement of VitD and Zn facilitates the Ca(2 +) absorption and attenuates the development of osteoporosis via down-regulation of osteoporosis-associated factors M-CSFR and RANKL, thus potentially constitutes an alternative therapy for the postmenopausal osteoporosis.”

Wang et al. · Authors' conclusion

Names both Calcium and Zinc in its title.

The ins and outs of mammary gland calcium and zinc transport: A brief review.

JDS communications · 2022 · PMID 37360130

Review

“In this brief review, we focus on the current understanding of how the essential divalent cations calcium (Ca) and zinc (Zn) are transported in the mammary gland (MG) with a focus on molecular regulation and the consequence of genotype. A deeper grasp of mechanisms and factors affecting Ca and Zn transport in the MG is important to understanding milk production, mineral output, and MG health to inform intervention design and novel diagnostic and therapeutic strategies in…”

Kelleher · From the abstract

Names both Calcium and Zinc in its title.

Zinc Modulation of Neuronal Calcium Sensor Proteins: Three Modes of Interaction with Different Structural Outcomes.

Biomolecules · 2022 · PMID 35883512

“Based on these data, and the results of structural bioinformatics analysis, NCSs can be divided into three categories: (1) physiological Ca2+/Zn2+ sensor proteins capable of binding exchangeable (signaling) zinc (recoverin and VILIP1), (2) pathological Ca2+/Zn2+ sensors responding only to aberrantly high free zinc concentrations by denaturation and aggregation (NCALD), and (3) Zn2+-resistant, Ca2+ sensor proteins (GCAP1, GCAP2).”

Baksheeva et al. · From the abstract

Names both Calcium and Zinc in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Zinc, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.