Supplement × Prescription·a caution·Strong evidence

Calcitriol + Calcium

Caution Strong evidence

Calcium supplements can combine with calcitriol to cause hypercalcemia, hypercalciuria, kidney stones, or soft tissue calcification.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Caution
Evidence
Strong
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionStrong evidence

What is happening. Calcium supplements can combine with calcitriol to cause hypercalcemia, hypercalciuria, kidney stones, or soft tissue calcification.

Mechanism. Calcitriol increases intestinal calcium absorption while supplements increase calcium load.

Recommendation. Use only the calcium amount prescribed and monitor serum calcium as directed.

Stack Score

How it moves the number.

Effect on the composite score

If both Calcitriol and Calcium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1U.S. National Library of Medicine. Calcitriol Capsules and Oral Solution US Prescribing Information. 2026.Needs sourceNo link

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.