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Supplement × Prescription·Evidence index

Calcitriol and Calcium: what the research found

PubMed indexes 8 records that name Calcitriol and Calcium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“Compared with a historical cohort, a PTH-guided protocol for Ca and calcitriol supplementation significantly reduces the postoperative hypocalcemia and hospital readmission rates in patients undergoing total thyroidectomy.”

Chindris et al. · 2023 · Human study · details

“1. Long-term low-dose conventional calcitriol therapy in combination with calcium supplementation could slow the progression of secondary hyperparathyroidism in some hemodialysis patients. 2. Low-dose therapy with active vitamin D-metabolites is effective only in hemodialysis patients with baseline serum PTH levels below 500 pg/ml and without pronounced hyperphosphatemia.”

Dimitrakov et al. · 1998 · Human study · details

“When rickets is present, calcium should be infused through a large vessel in doses high enough to produce normocalcemia, normophosphatemia, and suppression of parathyroid hormone. Only after radiologic healing has been observed can oral calcium therapy be introduced.”

The research

8 studies naming Calcitriol and Calcium.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

A Parathyroid Hormone-Guided Calcium and Calcitriol Supplementation Protocol Reduces Hypocalcemia-Related Readmissions Following Total Thyroidectomy.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2023 · PMID 36682414

Human subjects

“Compared with a historical cohort, a PTH-guided protocol for Ca and calcitriol supplementation significantly reduces the postoperative hypocalcemia and hospital readmission rates in patients undergoing total thyroidectomy.”

Chindris et al. · Authors' conclusion

Names both Calcitriol and Calcium in its title.

Effect of calcitriol and calcium on basal ganglia calcification in hypoparathyroidism: experimental models.

Journal of molecular endocrinology · 2022 · PMID 36445941

Animal study

“These models suggest that in 'drug-naïve' state, 1,25(OH)2D along with moderately elevated phosphate increases the expression of pro-osteogenic molecules to induce BGC. Although normalization of calcium in 'conventionally treated' state increased the expression of Opg, Osterix, Alp, and Cav2, calcification increased only in a subset, akin to variation in progression of BGC in hypoparathyroid patients on conventional therapy.”

Kar et al. · From the abstract

Names both Calcitriol and Calcium in its title.

Dynamic follow-up of the intact parathormone levels in hemodialysis patients treated with Rocaltrol and calcium.

Folia medica · 1998 · PMID 10371800

Human subjects

“1. Long-term low-dose conventional calcitriol therapy in combination with calcium supplementation could slow the progression of secondary hyperparathyroidism in some hemodialysis patients. 2. Low-dose therapy with active vitamin D-metabolites is effective only in hemodialysis patients with baseline serum PTH levels below 500 pg/ml and without pronounced hyperphosphatemia.”

Dimitrakov et al. · Authors' conclusion

Names both Calcitriol and Calcium in its title.

Calcium therapy for calcitriol-resistant rickets.

The Journal of pediatrics · 1992 · PMID 1331389

Human subjects

“When rickets is present, calcium should be infused through a large vessel in doses high enough to produce normocalcemia, normophosphatemia, and suppression of parathyroid hormone. Only after radiologic healing has been observed can oral calcium therapy be introduced.”

Hochberg et al. · From the abstract

Names both Calcitriol and Calcium in its title.

Tuberculosis and hypercalcemia

Acta medica portuguesa · 1996 · PMID 9005710

Case ReportsHuman subjects

“Antituberculosis drugs were started. The resolution of active tuberculosis was accompanied by normalization of serum calcium levels and by elevation above normal of serum concentration of parathormone.”

Santos et al. · From the abstract

Names Calcitriol and Calcium together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcitriol, Calcium, and several hundred other substances.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.