NSTK · 01.2026Independent supplement reference
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Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Calcium and Methylprednisolone: what the published research says

PubMed indexes 8 records that name Calcium and Methylprednisolone together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium and Methylprednisolone. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Calcium and Methylprednisolone.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Atorvastatin calcium in combination with methylprednisolone for the treatment of multiple sclerosis relapse.

International immunopharmacology · 2014 · PMID 25448497

Randomized Controlled Trial

“The levels of IL-13 and IL-10 in the combined treatment group were positively correlated with EDSS scores (r = 0.632, P = 0.001; r = 0.731, P = 0.002). Combined treatment with atorvastatin calcium and methylprednisolone can improve the outcomes of MS relapse compared with glucocorticosteroid alone.”

Li et al. · From the abstract

Names both Calcium and Methylprednisolone in its title.

Effect of low-dose methylprednisolone on calcium balance and bone composition in rats.

Journal of endocrinological investigation · 1997 · PMID 9492104

Comparative StudyAnimal study

“Mineral and calcium content was slightly increased in the MP group. According to these results, it seems that methylprednisolone while effective on HPA axis did not have any effect on calcium absorption and on bone calcium deposition in rats.”

Voulgaris et al. · From the abstract

Names both Calcium and Methylprednisolone in its title.

Negative association between serum calcium and glucocorticoid-induced hypertension in thyroid-associated ophthalmopathy patients treated with methylprednisolone.

Frontiers in endocrinology · 2025 · PMID 40290310

Human subjects

“Hypocalcemia was associated with glucocorticoid-induced hypertension in TAO patients. Further research is needed to confirm these findings in larger populations and to investigate whether calcium supplementation before glucocorticoid therapy may reduce such risk.”

Wang et al. · Authors' conclusion

Names both Calcium and Methylprednisolone in its title.

High dose intravenous methylprednisolone pulse therapy causes transient increase of serum calcium and phosphate levels.

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego · 2019 · PMID 31557136

Human subjects

“We observed a significant increase in serum Ca level on the next day after the 1st IVMP pulse both in patients with moderate-tosevere GO and with DON. Then, on the day 3, the decrease of serum Ca was noticed. In patients with moderate-to-severe GO, on the day 2 serum P showed a significant increase and then, it returned to basal level on the day 3.”

Rymuza et al. · Authors' conclusion

Names both Calcium and Methylprednisolone in its title.

In vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury.

Scientific reports · 2015 · PMID 25989524

Animal study

“MP treatment also improved the recovery of behavioral function post-injury. These findings suggest that MP exerts a neuroprotective effect on SCI treatment by attenuating progressive damage of axons, increasing blood flow, reducing calcium influx, and inhibiting the accumulation of microglia/macrophages after SCI.”

Tang et al. · From the abstract

Names both Calcium and Methylprednisolone in its title.

The effect of methylprednisolone on intracellular calcium of normal and dystrophic human skeletal muscle cells.

Neuroscience letters · 1999 · PMID 10430517

Human subjects

“The intracellular calcium activity, at rest and during calcium mobilizing drug superfusion protocols was recorded in normal and dystrophic human cocultured muscle cells. PDN (10 microM) pretreatment induced an elevation of the resting calcium concentration of 51, 34 and 38% in proliferating normal myoblasts, DMD myoblasts and DMD myotubes, respectively, while normal myotubes resting [Ca2+]i was not altered.”

Vandebrouck et al. · From the abstract

Names both Calcium and Methylprednisolone in its title.

Acute changes in calcium and bone metabolism during methylprednisolone pulse therapy in rheumatoid arthritis.

British journal of rheumatology · 1988 · PMID 3378125

Human subjects10 participants

“The effects could be divided into those occurring within 24 h: (a) a decrease in bone resorption (urinary excretion of calcium and hydroxyproline) and bone formation (alkaline phosphatase); (b) a decrease in renal excretion of calcium; (c) an increase in concentration of serum 1,25-dihydroxy-cholecalciferol and those secondary effects arising after 24 h; (d) a decrease in serum calcium due to the decrease in intestinal Ca absorption and the decrease in renal tubular…”

Bijlsma et al. · From the abstract

Names both Calcium and Methylprednisolone in its title.

Primary Hyperoxaluria Type 1: An Unexpected Diagnosis after Kidney Transplantation.

Kidney & blood pressure research · 2025 · PMID 40931511

Case ReportsHuman subjects

“PH1 is a rare cause of calcium oxalate nephrolithiasis and nephrocalcinosis and should be considered in the differential diagnosis of patients with progressive renal failure. This case highlights the importance of early diagnosis, which allows optimal supportive and/or RNAi therapy and appropriate qualification for kidney transplantation in cases of ESKD.”

Sobczyńska et al. · Authors' conclusion

Names Calcium and Methylprednisolone together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Methylprednisolone, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.