NutriStack
Calcium and Methylprednisolone, a synergy.
Like all glucocorticoids, methylprednisolone reduces calcium absorption and increases bone loss. Calcium supplementation is recommended for patients on chronic corticosteroid therapy.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Calcium and Methylprednisolone
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 3 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Like all glucocorticoids, methylprednisolone reduces calcium absorption and increases bone loss. Calcium supplementation is recommended for patients on chronic corticosteroid therapy.
Mechanism. Glucocorticoids antagonize vitamin D-dependent intestinal calcium absorption, increase renal calcium excretion, and directly inhibit osteoblast function.
Recommendation. Supplement 1000-1200mg calcium daily during chronic methylprednisolone therapy, combined with vitamin D3.
Sources (3)
- Buckley L et al. ACR guideline for glucocorticoid-induced osteoporosis prevention. Arthritis Care Res. 2017;69(8):1095-1110. PMID 28585410
- Liu C, Kuang X, Li K, Guo X, Deng Q, Li D. Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Food & Function. 2020. PMID 33237064
- Yao P, Bennett D, Mafham M et al.. Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis. JAMA Network Open. 2019. PMID 31860103
Stack Score
How this pair moves the number.
Effect on the composite score
If both Calcium and Methylprednisolone are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.