NutriStack
Calcium and Medroxyprogesterone, a synergy.
Depot medroxyprogesterone acetate (DMPA) is associated with a measurable but largely reversible decrease in bone mineral density during use. Adequate calcium intake (1000-1300 mg/day) is recommended for women on DMPA to support bone health, alongside vitamin D and weight-bearing exercise.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Calcium and Medroxyprogesterone
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Depot medroxyprogesterone acetate (DMPA) is associated with a measurable but largely reversible decrease in bone mineral density during use. Adequate calcium intake (1000-1300 mg/day) is recommended for women on DMPA to support bone health, alongside vitamin D and weight-bearing exercise.
Mechanism. DMPA suppresses ovarian estradiol production, removing estrogen's restraint on bone resorption. Adequate calcium supplies the substrate for bone formation and helps counter accelerated bone turnover.
Recommendation. Aim for 1000-1300 mg/day total calcium from diet plus supplements while on DMPA. Split supplemental doses (500 mg or less per serving) for best absorption, and take with vitamin D.
Sources (2)
- Guilbert ER, Brown JP, Kaunitz AM, et al. The use of depot-medroxyprogesterone acetate in contraception and its potential impact on skeletal health. Contraception. 2009;79(3):167-77. PMID 19185668
- Catalano A, Bellone F, Morabito N, et al. Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis. Nutrients. 2021;13(6):1878. PMID 34072655
Stack Score
How this pair moves the number.
Effect on the composite score
If both Calcium and Medroxyprogesterone are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.