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Supplement × Supplement·a caution·Moderate evidence

Calcium + Calcium Alpha-Ketoglutarate

Caution Moderate evidence

Calcium alpha-ketoglutarate delivers a meaningful amount of elemental calcium (approximately 20-25 percent by weight). Combining it with a separate calcium supplement can push total elemental calcium intake above the tolerable upper intake level (2,000-2,500 mg/day for adults), increasing risk of hypercalcemia, constipation, and possibly kidney stones.

Source citations
1
Pair type
Caution
Evidence
Moderate
Scope
Supplement × Supplement
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From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Calcium and Calcium Alpha-Ketoglutarate
Pair type
Caution
Evidence
Moderate
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionModerate evidence

What is happening. Calcium alpha-ketoglutarate delivers a meaningful amount of elemental calcium (approximately 20-25 percent by weight). Combining it with a separate calcium supplement can push total elemental calcium intake above the tolerable upper intake level (2,000-2,500 mg/day for adults), increasing risk of hypercalcemia, constipation, and possibly kidney stones.

Mechanism. Additive elemental calcium load; excess calcium intake raises serum and urinary calcium, increasing risk of hypercalcemia and stone formation in susceptible individuals.

Recommendation. Add the elemental calcium from the Ca-AKG product to your other calcium sources and keep total supplemental plus dietary calcium within recommended limits. Reduce or omit a standalone calcium supplement if combined intake is high.

Stack Score

How it moves the number.

Effect on the composite score

If both Calcium and Calcium Alpha-Ketoglutarate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. National Academies Press. 2011.Needs sourceNo link

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.