NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Ampicillin and Calcium: what the published research says

PubMed indexes 7 records that name Ampicillin and Calcium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Ampicillin and Calcium. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

7 studies naming Ampicillin and Calcium.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Highly biocompatible chitosan with super paramagnetic calcium ferrite (CaFe(2)O(4)) nanoparticle for the release of ampicillin.

International journal of biological macromolecules · 2017 · PMID 28087449

“The drug release kinetic data were fitted with different linear kinetic model equations and the best fit was obtained with Korsmeyer-Peppas model. The model drug ampicillin release from chitosan-CFNP was tested against staphylococcus epidermis bacteria through disc diffusion method for checking biocompatibility and antibacterial activity.”

Bilas et al. · From the abstract

Names both Ampicillin and Calcium in its title.

Formulation and characterization of calcium alginate beads containing ampicillin.

Pharmaceutical development and technology · 1998 · PMID 9653756

“The control of the drug for different time intervals depended on the molecular weight of the polymer used; however, the pH-change test showed that this capacity was much lower in the case of acid-treated particles. The results obtained show that the ampicillin beads prepared are suitable for intramammary therapy.”

Torre et al. · From the abstract

Names both Ampicillin and Calcium in its title.

Calcium ion sequestration by N-acylamino acids within the rectal membrane and the enhancement of the rectal absorption of sodium ampicillin in rats.

Journal of pharmaceutical sciences · 1989 · PMID 2760826

Animal study

“The amount of N-acylamino acids that penetrated into the rectal membrane was predicted by the product of the Rm value and the dose of N-acylamino acids. Thus, in the present study, it was demonstrated that the extent of the promoting effect of adjuvants at various doses on the membrane permeability may be predicted by multiplying the calcium ion sequestration capacity obtained in vitro by the lipophilicity and the dose applied to the rectal lumen of adjuvants.”

Wu et al. · From the abstract

Names both Ampicillin and Calcium in its title.

Treatment of Septic Tenosynovitis and Osteoarthritis in an American White Pekin (Anas platyrhynchos domesticus) with Repeated Intravenous Regional Limb Perfusion and Antibiotic-Impregnated Calcium Sulfate Beads.

Journal of avian medicine and surgery · 2023 · PMID 36935214

Case ReportsAnimal study

“Repeated antibiotic treatment through intravenous regional limb perfusion and concurrent placement of antibiotic-impregnated calcium sulfate beads is a practical treatment option for complicated distal limb infections in avian species. This therapeutic protocol has great potential in treating aggressive distal leg infections in many avian species because regional limb perfusion alone may not penetrate the joint adequately to achieve complete resolution of infection.”

Lacqua et al. · From the abstract

Names Ampicillin and Calcium together in an interaction, co-administration, or pharmacokinetic context.

A Novel Way of Treating Multidrug-resistant Enterococci.

North American journal of medical sciences · 2016 · PMID 27298819

Case Reports

“The exact mechanism of the daptomycin/ampicillin synergy effect is unclear. Current hypothesis suggests that ampicillin causes a reduction in the net positive charge of the bacterial surface, possibly by releasing lipoteichoic acid (LTA) from the cell wall. This process increases the ability of the cationic daptomycin/calcium complex to bind to the cell wall more effectively. Our case shows the clinical application of the same.”

Desai et al. · Authors' conclusion

Names Ampicillin and Calcium together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Ampicillin, Calcium, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.