What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Calcium + Cefixime pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·timing-sensitive·Emerging evidence

Calcium + Cefixime

Q: Can I take Calcium and Cefixime together?

Yes, if you separate them in time. Calcium and Cefixime have a documented timing-sensitive interaction. Calcium-containing supplements and antacids may bind cefixime in the gut, reducing its dissolution and absorption and potentially undermining treatment of the infection.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Emerging evidence

Calcium-containing supplements and antacids may bind cefixime in the gut, reducing its dissolution and absorption and potentially undermining treatment of the infection.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Calcium and Cefixime

Pair type

Timing Sensitive

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

Timing SensitiveEmerging evidence

What is happening. Calcium-containing supplements and antacids may bind cefixime in the gut, reducing its dissolution and absorption and potentially undermining treatment of the infection.

Mechanism. Calcium cations can complex with the beta-lactam structure and raise gastric pH, both of which can decrease the fraction of cefixime absorbed.

Recommendation. Take calcium supplements at least 2 hours apart from cefixime. Prioritize completing the antibiotic course on schedule.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

120

Stack Score

How it moves the number.

Effect on the composite score

If both Calcium and Cefixime are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Neuvonen PJ. Interactions with the absorption of oral antibiotics. Drugs. 1976.Needs sourceNo link

Check your full routine

One pair was the worked example.

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Open the interaction checker → Browse the research index