NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Calcium and Cholestyramine: what the published research says

PubMed indexes 4 records that name Calcium and Cholestyramine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium and Cholestyramine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Calcium and Cholestyramine.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Adsorption of methotrexate and calcium leucovorin onto cholestyramine in vitro.

International journal of pharmaceutics · 2004 · PMID 15196633

“The results suggest that cholestyramine may be a potentially useful adjunctive therapy in the treatment of an overdose of MTX. Consequently, cholestyramine may be of clinical value in patients who develop early renal function impairment whilst undergoing MTX therapy.”

Merino-Sanjuán et al. · From the abstract

Names both Calcium and Cholestyramine in its title.

Alterations in calcium, magnesium, iron, and zinc metabolism by dietary cholestyramine.

Digestive diseases and sciences · 1985 · PMID 3987479

Research Support, U.S. Gov't, Non-P.H.S.Animal study

“Alterations in calcium, magnesium, and zinc metabolism might be explained by inadequate vitamin D absorption from the intestine followed by an increased secretion of parathyroid hormone. A diminished iron absorption due to resin binding could account for the reported disturbance in iron balance.”

Watkins et al. · From the abstract

Names both Calcium and Cholestyramine in its title.

Effect of cholestyramine on the absorption of vitamin D3 and calcium.

Gut · 1969 · PMID 4318526

Animal study

“The absorption of 1 mg (47)calcium chloride was similar in both control and cholestyramine-fed rats, whether estimated by the whole body counting or the faecal excretion technique. These findings show that the administration of cholestyramine causes a reduction in the absorption of vitamin D(3)-(3)H but not of radiocalcium.”

Thompson et al. · From the abstract

Names both Calcium and Cholestyramine in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Cholestyramine, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.