From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Pair type
Timing Sensitive
Scope
Supplement × Prescription
Last verified
June 4, 2026
Timing SensitiveEmerging evidence
What is happening. Cholestyramine may bind or delay absorption of some supplements when taken simultaneously.
Mechanism. The resin can bind compounds in the gut and reduce absorption.
Recommendation. Separate calcium and other oral supplements from cholestyramine by at least 4 hours.
Stack Score
How it moves the number.
Effect on the composite score
If both Calcium and Cholestyramine are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1DailyMed. Cholestyramine US prescribing information. 2026.Needs sourceNo link