What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Calcium + Cefpodoxime pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·timing-sensitive·Moderate evidence

Calcium + Cefpodoxime

Q: Can I take Calcium and Cefpodoxime together?

Yes, if you separate them in time. Calcium and Cefpodoxime have a documented timing-sensitive interaction. Calcium supplements and calcium-containing antacids may reduce cefpodoxime absorption. Cefpodoxime proxetil depends on gastric acidity for adequate dissolution, and calcium carbonate antacids that raise gastric pH can meaningfully blunt absorption. Polyvalent calcium cations may also bind the drug in the gut.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Moderate evidence

Calcium supplements and calcium-containing antacids may reduce cefpodoxime absorption. Cefpodoxime proxetil depends on gastric acidity for adequate dissolution, and calcium carbonate antacids that raise gastric pH can meaningfully blunt absorption. Polyvalent calcium cations may also bind the drug in the gut.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Calcium and Cefpodoxime

Pair type

Timing Sensitive

Evidence

Moderate

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

Timing SensitiveModerate evidence

What is happening. Calcium supplements and calcium-containing antacids may reduce cefpodoxime absorption. Cefpodoxime proxetil depends on gastric acidity for adequate dissolution, and calcium carbonate antacids that raise gastric pH can meaningfully blunt absorption. Polyvalent calcium cations may also bind the drug in the gut.

Mechanism. Acid-suppressing/neutralizing calcium antacids raise intragastric pH and reduce dissolution and absorption of the acid-dependent prodrug cefpodoxime proxetil; divalent calcium can also chelate the drug, lowering bioavailability.

Recommendation. Separate dosing by at least 2 hours. Take cefpodoxime first, then the calcium supplement or calcium-based antacid afterward. Avoid taking calcium carbonate antacids around the same time as the antibiotic.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

120

Stack Score

How it moves the number.

Effect on the composite score

If both Calcium and Cefpodoxime are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Saathoff N, Lode H, Neider K, et al. Pharmacokinetics of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist. Antimicrob Agents Chemother. 1992.Needs sourceNo link
2Hughes GS, Heald DL, Barker KB, et al. The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil. Clin Pharmacol Ther. 1989.Needs sourceNo link

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