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Supplement × Prescription·Evidence index

Calcium and Fosfomycin: what the research found

PubMed indexes 8 records that name Calcium and Fosfomycin together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“This study provides relevant information on the pharmacokinetic profile of fosfomycin in women after oral administration as calcium salt. This population model may be very useful for establishing dosage recommendations of fosfomycin calcium to treat urinary tract infections in women.”

Isla et al. · 2024 · Human study · details

“In the over 60 years of age group, the corresponding microbiological outcome and clinical outcome rates evaluated for cure were 90.9 and 100%, respectively, and those evaluated for recurrence were 50.0 and 60.0%, respectively. These results indicate the usefulness of fosfomycin calcium administered at 1 g three times daily for 2 days for acute uncomplicated cystitis.”

Matsumoto et al. · 2011 · Human study · details

“Pharmacokinetic elimination of the two forms of fosfomycin was only moderately affected in elderly subjects; we observed lower urinary elimination, about 58 versus 28% of the dose in 24-h urines for the tromethamine salt and decreased renal clearance of both forms. However, the dosages of tromethamine and calcium fosfomycin need not be adjusted for elderly subjects who have endogenous creatinine clearances above…”

The research

8 studies naming Calcium and Fosfomycin.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Population pharmacokinetics of oral fosfomycin calcium in healthy women.

The Journal of antimicrobial chemotherapy · 2024 · PMID 39205651

Randomized Controlled Trial

“This study provides relevant information on the pharmacokinetic profile of fosfomycin in women after oral administration as calcium salt. This population model may be very useful for establishing dosage recommendations of fosfomycin calcium to treat urinary tract infections in women.”

Isla et al. · Authors' conclusion

Names both Calcium and Fosfomycin in its title.

Clinical effects of 2 days of treatment by fosfomycin calcium for acute uncomplicated cystitis in women.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2011 · PMID 20694571

Clinical TrialMulticenter Study

“In the over 60 years of age group, the corresponding microbiological outcome and clinical outcome rates evaluated for cure were 90.9 and 100%, respectively, and those evaluated for recurrence were 50.0 and 60.0%, respectively. These results indicate the usefulness of fosfomycin calcium administered at 1 g three times daily for 2 days for acute uncomplicated cystitis.”

Matsumoto et al. · From the abstract

Names both Calcium and Fosfomycin in its title.

Efficacy of calcium fosfomycin for the treatment of experimental infections of broiler chickens with Escherichia coli O78:K80.

Veterinary research communications · 2002 · PMID 12241095

Clinical TrialControlled Clinical TrialAnimal study

“The amount of antibiotic ingested in trial I was three times more than in trial 2. These results suggest that calcium fosfomycin is best used in the drinking water for the treatment of colibacillosis.”

Fernández et al. · From the abstract

Names both Calcium and Fosfomycin in its title.

Comparative pharmacokinetics of tromethamine fosfomycin and calcium fosfomycin in young and elderly adults.

Antimicrobial agents and chemotherapy · 1988 · PMID 3415215

Comparative StudyHuman subjects

“Pharmacokinetic elimination of the two forms of fosfomycin was only moderately affected in elderly subjects; we observed lower urinary elimination, about 58 versus 28% of the dose in 24-h urines for the tromethamine salt and decreased renal clearance of both forms. However, the dosages of tromethamine and calcium fosfomycin need not be adjusted for elderly subjects who have endogenous creatinine clearances above 50 ml/min per 1.73 m2.”

Borsa et al. · From the abstract

Names both Calcium and Fosfomycin in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Fosfomycin, and several hundred other substances.

Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.