Supplement researchSourced from PubMed and NIH
NutriStack
Free iPhone appUpdated September 28, 2026

Supplement × Prescription·Evidence index

Calcium and Prednisolone: what the research found

PubMed indexes 7 records that name Calcium and Prednisolone together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“In conclusion, the buffer media affects formulation behavior and drug release, with the bicarbonate media providing a better simulation of in vivo behavior. Moreover, the susceptibility of the formulations to bacterial action indicates their suitability as carriers for colonic drug delivery.”

Araujo et al. · 2013 · Human study · details

“Steroid could be considered as an adjunct therapy with calcium and vitamin D supplementation in patient whose Fahr's syndrome is secondary to primary hypoparathyroidism.”

Shah et al. · 2023 · Human study · details

“This is a remarkable case in which ACTH deficiency due to hypophysitis; thyroiditis; hypercalcaemia and pancreatitis developed in the same patient on ipilimumab and nivolumab combination therapy. We postulate that hypercalcaemia in this case was secondary to a combination of hyperthyroidism and secondary adrenal insufficiency.”

The research

7 studies naming Calcium and Prednisolone.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Short-term prednisolone therapy has minimal impact on calcium metabolism in dogs with atopic dermatitis.

Veterinary journal (London, England : 1997) · 2012 · PMID 22277720

Clinical TrialAnimal study

“There was no significant difference in any of the biochemical parameters measured following prednisolone treatment. This study indicates that prednisolone, used at a therapeutically effective dose, has minimal impact on calcium metabolism in dogs with atopic dermatitis.”

Kovalik et al. · From the abstract

Names both Calcium and Prednisolone in its title.

Zinc and Calcium Cations Combination in the Production of Floating Alginate Beads as Prednisolone Delivery Systems.

Molecules (Basel, Switzerland) · 2020 · PMID 32143377

“The proposed strategy allowed obtaining alginate beads with extremely high encapsulation efficiency values (up to 94%) and a very porous inner matrix conferring buoyancy in vitro in simulated gastric fluid up to 5 h. Moreover, in vivo, the best formulation, F4, resulted in the ability to prolong the anti-inflammatory effect up to 15 h compared with raw prednisolone.”

Russo et al. · From the abstract

Names both Calcium and Prednisolone in its title.

Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery.

Journal of pharmaceutical sciences · 2013 · PMID 23839971

Human subjects

“In conclusion, the buffer media affects formulation behavior and drug release, with the bicarbonate media providing a better simulation of in vivo behavior. Moreover, the susceptibility of the formulations to bacterial action indicates their suitability as carriers for colonic drug delivery.”

Araujo et al. · From the abstract

Names both Calcium and Prednisolone in its title.

Fahr's Syndrome Secondary to Primary Hypoparathyroidism Presenting With Seizures and the Role of Steroid Therapy.

Clinical medicine insights. Case reports · 2023 · PMID 37284033

Case Reports

“Steroid could be considered as an adjunct therapy with calcium and vitamin D supplementation in patient whose Fahr's syndrome is secondary to primary hypoparathyroidism.”

Shah et al. · Authors' conclusion

Names Calcium and Prednisolone together in an interaction, co-administration, or pharmacokinetic context.

Multiple endocrinopathies, hypercalcaemia and pancreatitis following combined immune checkpoint inhibitor use- case report and review of literature.

BMC endocrine disorders · 2021 · PMID 33639911

Case ReportsReviewHuman subjects

“This is a remarkable case in which ACTH deficiency due to hypophysitis; thyroiditis; hypercalcaemia and pancreatitis developed in the same patient on ipilimumab and nivolumab combination therapy. We postulate that hypercalcaemia in this case was secondary to a combination of hyperthyroidism and secondary adrenal insufficiency.”

Newman et al. · Authors' conclusion

Names Calcium and Prednisolone together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Prednisolone, and several hundred other substances.

Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.