Supplement researchSourced from PubMed and NIH
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Supplement × Prescription·Evidence index

Calcium and Ibandronate: what the research found

PubMed indexes 7 records that name Calcium and Ibandronate together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“This validated K-PD model is currently being used to evaluate a range of novel intermittent oral and i.v. ibandronate regimens in an ongoing clinical development programme.”

Pillai et al. · 2004 · Review or meta-analysis · details

“Additional sodium fluoride or ibandronate had no benefit over calcium and cholecalciferol alone in managing reduced BMD in CD.”

Klaus et al. · 2011 · Human study · details

“ibandronate injections effectively reduce bone turnover and increase BMD in Japanese women with osteoporosis. Ibandronate injections provide a new option for the treatment of osteoporosis.”

The research

7 studies naming Calcium and Ibandronate.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Therapeutic agents for disorders of bone and calcium metabolism: Ibandronate

Clinical calcium · 2007 · PMID 17211088

ReviewHuman subjects

“ibandronate injections effectively reduce bone turnover and increase BMD in Japanese women with osteoporosis. Ibandronate injections provide a new option for the treatment of osteoporosis.”

Hashimoto · From the abstract

Names both Calcium and Ibandronate in its title.

A semimechanistic and mechanistic population PK-PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis.

British journal of clinical pharmacology · 2004 · PMID 15563360

Meta-AnalysisHuman subjects3380 participants

“This validated K-PD model is currently being used to evaluate a range of novel intermittent oral and i.v. ibandronate regimens in an ongoing clinical development programme.”

Pillai et al. · Authors' conclusion

Names Calcium and Ibandronate together in an interaction, co-administration, or pharmacokinetic context.

Is there a role for bisphosphonates in vascular calcification in chronic kidney disease?

Bone · 2021 · PMID 33188959

Observational StudyHuman subjects

“Thus the efficacy of etidronate as treatment for soft tissue calcification brought with it a problematic tendency to cause osteomalacia. In contrast, conventional doses of nitrogen-containing bisphosphonates fail to yield circulating concentrations sufficient to exert direct anti-calcifying effects, at least in patients with good renal function and studies using alendronate and ibandronate have yielded inconsistent vascular outcomes.”

Hildebrand et al. · From the abstract

Names Calcium and Ibandronate together in an interaction, co-administration, or pharmacokinetic context.

Treatment of reduced bone density with ibandronate in dialysis patients.

Journal of nephrology · 2008 · PMID 18651540

Comparative StudyRandomized Controlled Trial

“Calcitriol dosage increased from 1.5 to 1.83 microg/week. In patients with renal osteodystrophy and ESRD, ibandronate significantly increased BMD and decreased bone turnover.”

Bergner et al. · From the abstract

Names Calcium and Ibandronate together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Ibandronate, and several hundred other substances.

Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.