NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Calcium Carbonate and Zinc: what the published research says

PubMed indexes 8 records that name Calcium Carbonate and Zinc together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium Carbonate and Zinc. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Calcium Carbonate and Zinc.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

The effect of calcium carbonate and calcium citrate on the absorption of zinc in healthy female subjects.

European journal of clinical nutrition · 1994 · PMID 8194505

Clinical TrialComparative StudyRandomized Controlled Trial

“The decrease in zinc absorption following the ingestion of zinc with different forms of calcium suggests that an antagonistic competition occurred between the minerals and that elemental calcium is the inhibiting factor.”

Argiratos et al. · Authors' conclusion

Names both Calcium Carbonate and Zinc in its title.

Effects of calcium carbonate and hydroxyapatite on zinc and iron retention in postmenopausal women.

The American journal of clinical nutrition · 1986 · PMID 3014855

Clinical TrialComparative StudyControlled Clinical TrialResearch Support, U.S. Gov't, Non-P.H.S.

“Iron retention, 6.3 +/- 2.0% with placebo, was significantly reduced with both calcium carbonate (43.3 +/- 8.8% of control, p = 0.002) and hydroxyapatite (45.9 +/- 10.0% of control, p = 0.003). Iron absorption may be significantly reduced when calcium supplements are taken with meals.”

Dawson-Hughes et al. · From the abstract

Names both Calcium Carbonate and Zinc in its title.

Biological activity of a chitosan-carboxymethylcellulose-zinc oxide and calcium carbonate in 3D scaffolds stabilized by physical links for bone tissue engineering.

Journal of biomaterials applications · 2023 · PMID 37025081

Animal study

“Osteoinduction assays to osteogenic lineage using runt-related transcription factor type 2 (RUNX2) and collagen type 1 (COL-1) antibodies allowed expression in differentiated cells. Therefore, the calcium carbonate-containing scaffolds stabilized by physical bonds have characteristics of being non-cytotoxic, bioactive, and osteoinductive, which motivate their use in future tests to evaluate their demeanor with rat models for bone engineering studies.”

Reyna-Urrutia et al. · From the abstract

Names both Calcium Carbonate and Zinc in its title.

Comparison of Phytoremediation Potential of Nerium indicum with Inorganic Modifier Calcium Carbonate and Organic Modifier Mushroom Residue to Lead-Zinc Tailings.

International journal of environmental research and public health · 2022 · PMID 36011987

“With the increase in modifier concentration, the enrichment coefficient increases about 1.75~52.94%, but the translocation factor decreases rapidly (20.01~64.46%). Clearly, both the calcium carbonate and mushroom residue amendment could promote the growth ability of Nerium indicum in lead−zinc tailings and strengthen the phytoremediation potential.”

Su et al. · From the abstract

Names both Calcium Carbonate and Zinc in its title.

Influence of zinc on the calcium carbonate biomineralization of Halomonas halophila.

Aquatic biosystems · 2012 · PMID 23198844

“We have demonstrated that the bacterial mineralization process can be influenced by zinc ions resulting in the modification of the synthesized calcium carbonate polymorph. In addition, the shape of the mineralized inorganic material is chancing through the presence of zinc ions. Furthermore, the moderately halophilic bacterium H. halophila can be applied for the decontamination of zinc from aqueous solutions.”

Rothenstein et al. · Authors' conclusion

Names both Calcium Carbonate and Zinc in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium Carbonate, Zinc, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.