What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Calcium Carbonate + Ciprofloxacin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Calcium Carbonate and Ciprofloxacin, timing-sensitive.

Q: Can I take Calcium Carbonate and Ciprofloxacin together?

Yes, if you separate them in time. Calcium Carbonate and Ciprofloxacin have a documented timing-sensitive interaction. Calcium carbonate, whether taken as an antacid or calcium supplement, binds ciprofloxacin in the gut and reduces its absorption by 30 to 50 percent. Even calcium-fortified foods such as fortified orange juice or dairy can produce clinically meaningful reductions. Lower antibiotic exposure can lead to treatment failure and resistance.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Calcium carbonate, whether taken as an antacid or calcium supplement, binds ciprofloxacin in the gut and reduces its absorption by 30 to 50 percent. Even calcium-fortified foods such as fortified orange juice or dairy can produce clinically meaningful reductions. Lower antibiotic exposure can lead to treatment failure and resistance.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Calcium Carbonate and Ciprofloxacin
Pair type: Timing Sensitive
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored timing-sensitive row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Timing Sensitive · Strong evidence

Timing Sensitive

What is happening. Calcium carbonate, whether taken as an antacid or calcium supplement, binds ciprofloxacin in the gut and reduces its absorption by 30 to 50 percent. Even calcium-fortified foods such as fortified orange juice or dairy can produce clinically meaningful reductions. Lower antibiotic exposure can lead to treatment failure and resistance.

Mechanism. Ca2+ cations form insoluble chelates with the 3-carboxyl and 4-oxo groups of the fluoroquinolone core, preventing intestinal absorption.

Recommendation. Take ciprofloxacin at least 2 hours before or 6 hours after calcium carbonate. Avoid taking with calcium-fortified drinks or dairy in the same window.

Minimum separation. 360

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Calcium Carbonate and Ciprofloxacin are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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