NutriStack
Amiodarone and Ciprofloxacin, contraindicated.
Both amiodarone and fluoroquinolones independently prolong the QT interval. Concurrent use creates additive QT prolongation risk, potentially leading to torsades de pointes, a life-threatening ventricular arrhythmia.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Amiodarone and Ciprofloxacin
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. Both amiodarone and fluoroquinolones independently prolong the QT interval. Concurrent use creates additive QT prolongation risk, potentially leading to torsades de pointes, a life-threatening ventricular arrhythmia.
Mechanism. Amiodarone blocks multiple cardiac ion channels including hERG potassium channels. Fluoroquinolones also block hERG channels. Additive blockade prolongs cardiac repolarization and QT interval.
Recommendation. Avoid concurrent use if possible. If unavoidable, perform baseline ECG, monitor QTc closely, and discontinue if QTc exceeds 500 ms. Ensure electrolytes (K+, Mg2+) are normal.
Sources (2)
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amiodarone and Ciprofloxacin are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.