What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Amiodarone + Iodine pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Amiodarone and Iodine, a caution.

Q: Can I take Amiodarone and Iodine together?

Possibly, but with caution. Amiodarone and Iodine have a documented caution-tier interaction. Amiodarone contains a large iodine load and is strongly associated with thyroid dysfunction. Extra iodine from supplements can further increase iodine exposure and may precipitate hypothyroidism or thyrotoxicosis, especially in people with nodular thyroid disease or autoimmune thyroid disease. Thyroid shifts can destabilize heart rhythm and worsen heart failure symptoms.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Amiodarone contains a large iodine load and is strongly associated with thyroid dysfunction. Extra iodine from supplements can further increase iodine exposure and may precipitate hypothyroidism or thyrotoxicosis, especially in people with nodular thyroid disease or autoimmune thyroid disease. Thyroid shifts can destabilize heart rhythm and worsen heart failure symptoms.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Amiodarone and Iodine
Pair type: Caution
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Moderate evidence

Caution

What is happening. Amiodarone contains a large iodine load and is strongly associated with thyroid dysfunction. Extra iodine from supplements can further increase iodine exposure and may precipitate hypothyroidism or thyrotoxicosis, especially in people with nodular thyroid disease or autoimmune thyroid disease. Thyroid shifts can destabilize heart rhythm and worsen heart failure symptoms.

Mechanism. Excess iodine can trigger Wolff-Chaikoff hypothyroidism or Jod-Basedow thyrotoxicosis in susceptible thyroid tissue. Amiodarone adds iodine exposure and also inhibits thyroid hormone deiodination and can cause direct thyroid cytotoxicity.

Recommendation. Avoid iodine supplements while taking amiodarone unless your prescriber specifically treats a documented deficiency. Follow the thyroid lab schedule your clinician recommends, and report new palpitations, heat or cold intolerance, weight change, tremor, or unusual fatigue.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Amiodarone and Iodine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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