NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Amiodarone and Iodine: what the published research says

PubMed indexes 4 records that name Amiodarone and Iodine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Amiodarone and Iodine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Amiodarone and Iodine.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Iodine kinetic studies during amiodarone treatment.

The Journal of clinical endocrinology and metabolism · 1986 · PMID 3944239

Human subjects15 participants

“increased T4, free T4, and rT3 and decreased T3, while remaining clinically euthyroid. The massive increase in available inorganic iodide during amiodarone treatment is probably responsible for the induction of both the hypothyroidism and the thyrotoxicosis that can occur in patients receiving the drug.”

Rao et al. · From the abstract

Names both Amiodarone and Iodine in its title.

Dronedarone: a safety comparison to amiodarone.

Current drug safety · 2010 · PMID 20210734

Comparative StudyReviewHuman subjects

“Although the potential differences between dronedarone and amiodarone have been evaluated there have been no direct comparison trials published to date. This article reviews the chemistry, antiarrhythmic effects, pharmacokinetics, efficacy, adverse effects and drug interactions of dronedarone.”

Clem et al. · From the abstract

Names Amiodarone and Iodine together in an interaction, co-administration, or pharmacokinetic context.

Complex drug-drug-disease interactions between amiodarone, warfarin, and the thyroid gland.

Medicine · 2004 · PMID 15028964

Case ReportsReviewHuman subjects

“We review the literature on the mechanisms of the complex drug-drug and drug-disease interactions within the thyroid gland, warfarin, and amiodarone triad. Given that significant thyroid disorders may be only mildly symptomatic and thus may escape clinical detection, we suggest that thyroid function should be tested in any patient with otherwise unexplained changes in warfarin dose requirements, particularly if concomitantly treated with amiodarone.”

Kurnik et al. · From the abstract

Names Amiodarone and Iodine together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Amiodarone, Iodine, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.