NutriStack
Iodine and Selenium, a synergy.
Selenium is critical for thyroid hormone metabolism. Selenoproteins (deiodinases) convert T4 to active T3, and glutathione peroxidase protects the thyroid from peroxide damage.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Selenium is critical for thyroid hormone metabolism. Selenoproteins (deiodinases) convert T4 to active T3, and glutathione peroxidase protects the thyroid from peroxide damage.
Mechanism. Type I, II, and III iodothyronine deiodinases are selenoenzymes that convert T4→T3. GPx protects thyrocytes from H2O2 generated during thyroid hormone synthesis.
Recommendation. Ensure adequate selenium when supplementing iodine. Selenium deficiency with iodine supplementation can worsen thyroid damage.
Sources (1)
Stack Score
How this pair moves the number.
Effect on the composite score
If both Iodine and Selenium are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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