NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Methimazole and Selenium: what the published research says

PubMed indexes 8 records that name Methimazole and Selenium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Methimazole and Selenium. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Methimazole and Selenium.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

A pilot study on the beneficial effects of additional selenium supplementation to methimazole for treating patients with Graves’ disease.

Turkish journal of medical sciences · 2019 · PMID 31023005

Randomized Controlled Trial

“We suggest that the combined use of MMI and Se could improve the thyroid activity in patients, which may provide an effective therapy for the treatment of GD in clinical settings.”

Xu et al. · Authors' conclusion

Names both Methimazole and Selenium in its title.

Effects of selenium on short-term control of hyperthyroidism due to Graves' disease treated with methimazole: results of a randomized clinical trial.

Journal of endocrinological investigation · 2017 · PMID 27734319

Randomized Controlled Trial

“Our study, carried out in a selenium-sufficient cohort of GD patients, failed to show an adjuvant role of selenium in the short-term control of hyperthyroidism. However, selenium might be beneficial in patients from selenium-deficient areas, as well as in the long-term outcome of antithyroid treatment.”

Leo et al. · Authors' conclusion

Names both Methimazole and Selenium in its title.

Clinical effect of methimazole combined with selenium in the treatment of toxic diffuse goiter in children.

World journal of clinical cases · 2022 · PMID 35211552

103 participants

“Methimazole combined with selenium can effectively treat Graves' disease in children, reduce the expression of TRAb, TPOAb, FT4 and inflammatory factors, and improve the curative effect. Thus, the combined treatment warrants further clinical research.”

Zhang et al. · Authors' conclusion

Names both Methimazole and Selenium in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Methimazole, Selenium, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.