NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Iodine and Lithium: what the published research says

PubMed indexes 8 records that name Iodine and Lithium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Iodine and Lithium. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Iodine and Lithium.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Lithium as an adjunct to radioactive iodine for the treatment of hyperthyroidism: a systematic review and meta-analysis.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2014 · PMID 24793920

Meta-AnalysisSystematic ReviewHuman subjects

“The observational trials demonstrated significant improvement in the cure rate of hyperthyroidism when lithium is added to RAI. The improvements shown in the interventional trials did not reach statistical significance due to the effect of a single, large negative trial.”

Kessler et al. · Authors' conclusion

Names both Iodine and Lithium in its title.

The Iodine-Dextrin-Lithium Complex: Morphology, Antibacterial Activity, and Cytotoxicity.

Molecules (Basel, Switzerland) · 2025 · PMID 41471843

Human subjects

“Thus, IDLC demonstrates non-specific cytotoxicity at high concentrations, consistent with its iodine content. The research confirms that iodine can be effectively stabilized within a dextrin-lithium framework to yield a biologically active, thermally resistant complex, suitable for pharmaceutical use.”

Shepilov et al. · From the abstract

Names both Iodine and Lithium in its title.

Hydrogen-Bonded Organic Framework for High-Performance Lithium/Sodium-Iodine Organic Batteries.

Angewandte Chemie (International ed. in English) · 2022 · PMID 36196009

“The I2 /HOF@Ti3 C2 Tx exhibits large reversible capacities of 260.2 and 207.6 mAh g-1 at 0.2 C after repeated cycling for Li-I2 and Na-I2 batteries, respectively. This work can gain insights into the HOF-related energy storage application with reversible iodine encapsulation and its related redox reaction mechanisms with Li and Na metal ions.”

Guo et al. · From the abstract

Names both Iodine and Lithium in its title.

A 3D and Stable Lithium Anode for High-Performance Lithium-Iodine Batteries.

Advanced materials (Deerfield Beach, Fla.) · 2019 · PMID 31222829

“A fuel cell with such an electrode and a lithium-iodine cathode shows impressive long-term stability with a capacity retention of around 100% over 4000 cycles and enhanced high-rate capability. These results demonstrate the promising applications of 3D stable lithium metal anodes in next-generation rechargeable batteries.”

Li et al. · From the abstract

Names both Iodine and Lithium in its title.

A room-temperature refuelable lithium, iodine and air battery.

Scientific reports · 2017 · PMID 28747774

“Li-SES and iodine are then electrochemically generated during charge as is confirmed by UV-VIS and a qualitative test. We have also conducted proof-of-concept tests for an "indirect lithium-air" cell in which iodine is reduced at the cathode and subsequently is catalytically re-oxidized by oxygen dissolved in the catholyte.”

Tan et al. · From the abstract

Names both Iodine and Lithium in its title.

Rechargeable Lithium-Iodine Batteries with Iodine/Nanoporous Carbon Cathode.

Nano letters · 2015 · PMID 26241461

“For the demonstration of application, soft-package batteries with Al-plastic film were assembled, displaying energy densities of 475 Wh/kg by mass of Li and iodine, and 136 Wh/kg by total mass of the battery. The use of nanoporous carbon to adsorb iodine at room-temperature represents a new and promising direction for realizing high-performance cathode for rechargeable Li-iodine batteries.”

Zhao et al. · From the abstract

Names both Iodine and Lithium in its title.

Impact of lithium on radioactive iodine therapy for hyperthyroidism.

Indian journal of endocrinology and metabolism · 2014 · PMID 25285284

“RAI therapy combined with lithium showed a trend towards higher cure rate, safe and time to cure was less than RAI alone. Hence RAI combined with lithium is a better option in the management of hyperthyroidism than RAI alone.”

Lingudu et al. · Authors' conclusion

Names both Iodine and Lithium in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Iodine, Lithium, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.