NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Fish Oil and Lithium: what the published research says

PubMed indexes 8 records that name Fish Oil and Lithium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Fish Oil and Lithium. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Fish Oil and Lithium.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Removal of lithium from aqueous solutions by solid-phase extraction using sawdust loaded with magnetite nanoparticles and study of apoptosis, MDA and 8-OHdG caused by lithium toxicity in fish brain.

Toxicology and industrial health · 2023 · PMID 36760134

Animal study

“Optimal conditions for the SPE process were defined and it was found that lithium could be removed from solution onto the MNLS surface with a high yield of about 96%. The results of the study are crucial for proposing a simple and applicable high performance method.”

Öter et al. · From the abstract

Names both Fish Oil and Lithium in its title.

Omega-3 fatty acids supplementation with lithium and aripiprazole for improving the balance of circulating hormones and brain neurotransmitters in manic mice model.

Naunyn-Schmiedeberg's archives of pharmacology · 2018 · PMID 29290022

Animal study

“However, GSK3β and pAkt in the brain showed no significant differences in the level of expression. These results reveal that the combination of lithium and aripiprazole supplemented with omega-3 fatty acids provide protective effects against MPD-induced neuroendocrine system and multiple neurochemical abnormalities.”

Arunagiri et al. · From the abstract

Names both Fish Oil and Lithium in its title.

Combination of omega-3 Fatty acids, lithium, and aripiprazole reduces oxidative stress in brain of mice with mania.

Biological trace element research · 2014 · PMID 25035188

Animal study

“There is no remarkable difference in the effect of creatine kinase (CK) activity between MPD-induced manic model and the treatment groups. Therefore, our results demonstrate that oxidative stress imbalance and mild insignificant CK alterations induced by administration of MPD can be restored back to normal physiological levels through omega-3 fatty acids combined with lithium and aripiprazole that attributes to effective prevention against mania in adult male Swiss albino…”

Arunagiri et al. · From the abstract

Names both Fish Oil and Lithium in its title.

Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment.

Journal of psychiatric research · 2008 · PMID 17628596

Evaluation StudyResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, Non-P.H.S.Animal study

“These data indicate that alterations in fatty acid composition resulting from dietary-induced omega-3 fatty acid deficiency augment the development of AMPH-induced behavioral sensitization in a manner that is prevented by chronic lithium treatment. The implications of these findings for understanding the contribution of omega-3 fatty acid deficiency to the pathophysiology and progression of bipolar disorder are discussed.”

McNamara et al. · Authors' conclusion

Names both Fish Oil and Lithium in its title.

The use of fish in studying the behavioural effects of lithium.

Pharmacopsychiatria · 1981 · PMID 7034007

ReviewAnimal study

“Lithium effects have been observed on various aspects of the behaviour of fish, and in particular upon social aggregation, aggression, visual and lateral line sensory perception, memory, and alcohol tolerance. The results of these studies are reviewed and the findings related to a model of lithium action based upon attenuation of sensory information processing.”

Johnson · From the abstract

Names both Fish Oil and Lithium in its title.

Fish oil and cyclosporin A-induced renal hypoperfusion in kidney-transplanted patients.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 1995 · PMID 8559499

Clinical TrialControlled Clinical Trial

“Fish oil supplementation had no effect on baseline renal function or CsA-induced hypoperfusion in stable renal transplant recipients treated with a low maintenance dose of CsA.”

Hansen et al. · Authors' conclusion

Names Fish Oil and Lithium together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Fish Oil, Lithium, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.