NutriStack
Bromelain and Fish Oil, a caution.
Both have mild antiplatelet activity; combined chronic use can additively raise bleeding tendency.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both have mild antiplatelet activity; combined chronic use can additively raise bleeding tendency.
Mechanism. Fish oil EPA reduces thromboxane A2; bromelain reduces platelet aggregation.
Recommendation. Use together with awareness of bleeding risk. Stop both before surgery.
Sources (2)
- Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58(9):1234-45. PMID 11577981
- Javaid M et al. Bleeding Risk in Patients Receiving Omega-3 Polyunsaturated Fatty Acids: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Am Heart Assoc. 2024;13(10):e032390. PMID 38742535
Stack Score
How this pair moves the number.
Effect on the composite score
If both Bromelain and Fish Oil are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.