NutriStack
Bromelain and Serrapeptase, a synergy.
Serrapeptase and bromelain are commonly combined as systemic proteolytic enzymes and appear to act in a complementary way to reduce post-surgical edema, pain, and inflammation.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Bromelain and Serrapeptase
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Serrapeptase and bromelain are commonly combined as systemic proteolytic enzymes and appear to act in a complementary way to reduce post-surgical edema, pain, and inflammation.
Mechanism. Both are systemic proteolytic enzymes: bromelain inhibits bradykinin generation and modulates arachidonic acid metabolism, while serrapeptase degrades inflammatory exudate and non-vital tissue. Their anti-inflammatory pathways are complementary.
Recommendation. Reasonable to combine for short-term anti-inflammatory support. Take on an empty stomach (away from food) for systemic enzyme effect, and monitor for additive bleeding tendency if also on blood thinners.
Sources (2)
- A Comparative Study of the Anti-Inflammatory Properties of Bromelain and Serratiopeptidase as Add-On Therapy Following Impacted Third Molar Surgery, 2020
- Effects of Systemic Enzyme Supplements on Symptoms and Quality of Life in Patients with Pulmonary Fibrosis: A Pilot Study, 2021
Stack Score
How this pair moves the number.
Effect on the composite score
If both Bromelain and Serrapeptase are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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