NutriStack
Serrapeptase and Turmeric/Curcumin, a caution.
Serrapeptase has fibrinolytic activity and curcumin has antiplatelet activity, so the combination can additively reduce clotting and increase bleeding risk while also providing additive anti-inflammatory effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Serrapeptase and Turmeric/Curcumin
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Serrapeptase has fibrinolytic activity and curcumin has antiplatelet activity, so the combination can additively reduce clotting and increase bleeding risk while also providing additive anti-inflammatory effects.
Mechanism. Curcumin inhibits platelet aggregation and thromboxane formation, while serrapeptase degrades fibrin and has reported antithrombotic properties; acting on different hemostatic steps, their effects on bleeding can be additive.
Recommendation. Use together cautiously, especially if on anticoagulant or antiplatelet drugs, and discontinue both 7 to 10 days before surgery or dental procedures. Watch for bruising or prolonged bleeding.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Serrapeptase and Turmeric/Curcumin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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