What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Amlodipine + Turmeric/Curcumin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Amlodipine and Turmeric/Curcumin, a caution.

Q: Can I take Amlodipine and Turmeric/Curcumin together?

Possibly, but with caution. Amlodipine and Turmeric/Curcumin have a documented caution-tier interaction. Curcumin inhibits CYP3A4 and intestinal P-glycoprotein, both of which contribute to amlodipine clearance and absorption. In a rat pharmacokinetic study, curcumin pretreatment more than doubled amlodipine AUC and Cmax, suggesting that high-dose curcumin or curcumin phytosome formulations could push amlodipine levels into a range that causes hypotension, edema, or reflex tachycardia in humans.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Curcumin inhibits CYP3A4 and intestinal P-glycoprotein, both of which contribute to amlodipine clearance and absorption. In a rat pharmacokinetic study, curcumin pretreatment more than doubled amlodipine AUC and Cmax, suggesting that high-dose curcumin or curcumin phytosome formulations could push amlodipine levels into a range that causes hypotension, edema, or reflex tachycardia in humans.

2 primary source citations. Emerging evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Amlodipine and Turmeric/Curcumin
Pair type: Caution
Evidence (highest tier): Emerging
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Emerging evidence

Caution

What is happening. Curcumin inhibits CYP3A4 and intestinal P-glycoprotein, both of which contribute to amlodipine clearance and absorption. In a rat pharmacokinetic study, curcumin pretreatment more than doubled amlodipine AUC and Cmax, suggesting that high-dose curcumin or curcumin phytosome formulations could push amlodipine levels into a range that causes hypotension, edema, or reflex tachycardia in humans.

Mechanism. Curcumin inhibits CYP3A4 (IC50 ~2.7 µM) and downregulates intestinal P-gp. Amlodipine is a CYP3A4 substrate, so reduced enzyme activity raises systemic exposure and prolongs half-life.

Recommendation. If you take amlodipine, keep turmeric to culinary amounts and avoid high-dose curcumin supplements unless your prescriber agrees. If you do use a curcumin product, separate it from amlodipine by at least 4 hours, check blood pressure for 1-2 weeks, and stop if you develop new dizziness or swelling.

Minimum separation. 240

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Amlodipine and Turmeric/Curcumin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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