NutriStack
Amlodipine and Coenzyme Q10, a synergy.
CoQ10 produces a small but consistent reduction in systolic blood pressure (about 3-5 mmHg) and improves endothelial function, complementing amlodipine's antihypertensive effect. The combination is generally beneficial and well-tolerated, especially in patients with metabolic syndrome or coexisting heart failure.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Amlodipine and Coenzyme Q10
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. CoQ10 produces a small but consistent reduction in systolic blood pressure (about 3-5 mmHg) and improves endothelial function, complementing amlodipine's antihypertensive effect. The combination is generally beneficial and well-tolerated, especially in patients with metabolic syndrome or coexisting heart failure.
Mechanism. CoQ10 improves mitochondrial energy production in vascular smooth muscle and endothelium, raising nitric oxide bioavailability and reducing systemic vascular resistance. These effects add to amlodipine's vasodilation.
Recommendation. CoQ10 at 100-200 mg/day combined with amlodipine is appropriate for most patients with hypertension or cardiometabolic disease. Monitor blood pressure for 4 weeks after starting, and adjust amlodipine with your prescriber if readings fall consistently below your goal.
Sources (2)
- Rosenfeldt FL, Haas SJ, Krum H, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007;21(4):297-306. PMID 17287847
- Zhao D, Liang Y, Dai S, et al. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2022;13(6):2180-2194. PMID 36130103
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amlodipine and Coenzyme Q10 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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