What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Coenzyme Q10 + Fenofibrate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·timing-sensitive·Emerging evidence

Coenzyme Q10 + Fenofibrate

Q: Can I take Coenzyme Q10 and Fenofibrate together?

Yes, if you separate them in time. Coenzyme Q10 and Fenofibrate have a documented timing-sensitive interaction. Fibrates, like statins, may modestly lower endogenous coenzyme Q10 (ubiquinone) levels, and myopathy risk rises when fenofibrate is combined with a statin. CoQ10 supplementation is sometimes used to support patients with muscle symptoms, though evidence for symptomatic benefit is mixed. The two do not have a harmful pharmacokinetic interaction.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Emerging evidence

Fibrates, like statins, may modestly lower endogenous coenzyme Q10 (ubiquinone) levels, and myopathy risk rises when fenofibrate is combined with a statin. CoQ10 supplementation is sometimes used to support patients with muscle symptoms, though evidence for symptomatic benefit is mixed. The two do not have a harmful pharmacokinetic interaction.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Coenzyme Q10 and Fenofibrate

Pair type

Timing Sensitive

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

Timing SensitiveEmerging evidence

What is happening. Fibrates, like statins, may modestly lower endogenous coenzyme Q10 (ubiquinone) levels, and myopathy risk rises when fenofibrate is combined with a statin. CoQ10 supplementation is sometimes used to support patients with muscle symptoms, though evidence for symptomatic benefit is mixed. The two do not have a harmful pharmacokinetic interaction.

Mechanism. Fibrates can reduce circulating ubiquinone, and the fibrate-statin combination interferes with the mevalonate pathway that produces CoQ10, potentially contributing to myopathy. Supplemental CoQ10 aims to replete the mitochondrial electron-transport cofactor.

Recommendation. CoQ10 may be taken alongside fenofibrate, particularly if muscle aches occur on combined fibrate-statin therapy. It does not replace evaluation of unexplained muscle pain, weakness, or dark urine, which should prompt creatine kinase testing.

Stack Score

How it moves the number.

Effect on the composite score

If both Coenzyme Q10 and Fenofibrate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Banach M, et al. Statin therapy and plasma coenzyme Q10 concentrations: a systematic review and meta-analysis. Pharmacol Res. 2015.Needs sourceNo link

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Open the interaction checker → Browse the research index