NSTK · 01.2026Independent supplement reference

Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Black Seed Oil and Turmeric/Curcumin: what the published research says

PubMed indexes 7 records that name Black Seed Oil and Turmeric/Curcumin together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Reviews & meta-analyses

Read the studies ↓ How we select sources

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Black Seed Oil and Turmeric/Curcumin. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

A study appearing here is not proof that an interaction exists. Two substances can be named together in a paper that never tested them in combination, and a source listed as background may cover only one of them.
Findings are quoted from each abstract as the authors wrote them. NutriStack has not re-analysed, pooled, or reconciled them, and they may disagree with each other.
NutriStack’s own interaction assessment for this pair is not published here. It has not completed qualified-human clinical review, so it is withheld from search. See the publication gate.
Nothing here is medical advice. Decisions about prescription medication and supplements belong with your prescriber or pharmacist, who can see your full regimen.

The research

7 studies naming Black Seed Oil and Turmeric/Curcumin.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

The ex vivo effects of ethanolic extractions of black cumin seed, turmeric root, and Ceylon cinnamon bark on the human gut microbiota.

PloS one · 2025 · PMID 41343511

Human subjects

Names both Black Seed Oil and Turmeric/Curcumin in its title.

Black Seed Oil-Based Curcumin Nanoformulations Ameliorated Cuprizone-Induced Demyelination in the Mouse Hippocampus.

Molecular neurobiology · 2025 · PMID 38890237

Animal study

Names both Black Seed Oil and Turmeric/Curcumin in its title.

The Efficacy of Nigella sativa L. and Curcumin Nanomicelle Alone or Together on Lipid Profile, Glycemic Control Indices, and Serum 17-Β Estradiol in Postmenopausal Women.

Journal of caring sciences · 2023 · PMID 38020740

“NS, CN and NS-CN improved lipid profiles, blood sugar, and hormone levels. However, this improvement was significant in glycemic indices and estrogen levels compared to the placebo group. No superiority of combined NS-CN over NS or CN was found in this trial.”
Sadeghzadeh et al. · Authors' conclusion

Names both Black Seed Oil and Turmeric/Curcumin in its title.

Efficacy of nanomicelle curcumin, Nigella sativa oil, and their combination on bone turnover markers and their safety in postmenopausal women with primary osteoporosis and osteopenia: A triple-blind randomized controlled trial.

Food science & nutrition · 2021 · PMID 35154688

Names both Black Seed Oil and Turmeric/Curcumin in its title.

Antitumoral Effects of Curcumin (Curcuma longa L.) and Thymoquinone (Nigella sativa L.) on Neuroblastoma Cell Lines.

Complementary medicine research · 2021 · PMID 33075785

Human subjects

“Both substances showed anti-tumoral properties on neuroblastoma cell lines and should be further investigated as therapeutic agents.”
Korff et al. · Authors' conclusion

Names both Black Seed Oil and Turmeric/Curcumin in its title.

Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia · 2017 · PMID 29265038

Animal study

“This study shows that the mixed extracts of N. sativa and CL have positive synergistic effects on renal damage in nephropathy induced by ADR in rats.”
Mohebbati et al. · From the abstract

Names both Black Seed Oil and Turmeric/Curcumin in its title.

The efficacy and safety of herbal medicines for glycaemic control and insulin resistance in individuals with type 2 diabetes: an umbrella review.

BMC complementary medicine and therapies · 2025 · PMID 41029669

Systematic ReviewHuman subjects

“Current evidence supports the use of ginger and turmeric for glycaemic control in type 2 diabetes, however, given the high clinical heterogeneity and low quality of the review, our confidence in this finding is somewhat limited. Herbal medicines should be used only as an adjunct to conventional treatment, with shared decision-making between clinicians and patients.”
Li et al. · Authors' conclusion

Names Black Seed Oil and Turmeric/Curcumin together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

Selection. These records were found by searching PubMed titles and abstracts for both substance names alongside interaction and pharmacokinetic terms. Relevant work that phrases things differently, or is not indexed in PubMed, will be missing.
No effect size. The quoted conclusions are the authors’ words about their own study. We have not extracted effect direction or magnitude, and a single study’s conclusion is not a consensus.
Population mismatch. Findings in healthy volunteers, animals, or a specific patient group may not transfer to you, your dose, or your formulation.
Absence is not safety. Few published studies means the combination is under-studied, which is not the same as established as safe.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Black Seed Oil, Turmeric/Curcumin, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

Get NutriStack free → Read the methodology

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.