NutriStack
Black Seed Oil and Fish Oil, a caution.
Both can modestly lower blood pressure and affect platelet function, so combining them may produce additive reductions in blood pressure and a small additive antiplatelet effect.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Black Seed Oil and Fish Oil
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both can modestly lower blood pressure and affect platelet function, so combining them may produce additive reductions in blood pressure and a small additive antiplatelet effect.
Mechanism. Omega-3 fatty acids in fish oil reduce platelet aggregation and modestly lower blood pressure, while black seed oil also has documented blood pressure lowering and mild antiplatelet activity; the effects are additive.
Recommendation. Generally well tolerated, but monitor blood pressure if hypotension-prone and watch for easy bruising or bleeding, especially around surgery or with anticoagulants.
Sources (2)
- Sahebkar A et al, Nigella sativa supplementation and blood pressure: a systematic review and meta-analysis, Journal of Hypertension, 2016
- Mori TA, Omega-3 fatty acids and blood pressure, Cellular and Molecular Biology, 2010. Omega-3 fatty acids and blood pressure. Cell Mol Biol (Noisy-le-grand). 2010. PMID 20196972
Stack Score
How this pair moves the number.
Effect on the composite score
If both Black Seed Oil and Fish Oil are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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