NutriStack
CLA and Fish Oil, a synergy.
Combining CLA with fish oil may offset CLA's tendency to worsen some lipid and inflammatory markers, since omega-3s improve triglycerides and have anti-inflammatory effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Combining CLA with fish oil may offset CLA's tendency to worsen some lipid and inflammatory markers, since omega-3s improve triglycerides and have anti-inflammatory effects.
Mechanism. Higher-dose CLA has in some studies been linked to reduced insulin sensitivity and adverse lipid shifts, whereas fish oil omega-3s lower triglycerides and reduce inflammation, potentially mitigating these effects.
Recommendation. A sensible pairing; fish oil can counterbalance potential unfavorable lipid or insulin-sensitivity effects sometimes seen with CLA. No special timing needed.
Sources (2)
- Riserus U et al, Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance, Diabetes Care, 2002
- Skulas-Ray AC et al, Omega-3 fatty acids for the management of hypertriglyceridemia, Circulation, 2019
Stack Score
How this pair moves the number.
Effect on the composite score
If both CLA and Fish Oil are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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