NSTK · 01.2026Independent supplement reference

Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Clopidogrel and Fish Oil: what the published research says

PubMed indexes 7 records that name Clopidogrel and Fish Oil together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Reviews & meta-analyses

Read the studies ↓ How we select sources

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Clopidogrel and Fish Oil. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

A study appearing here is not proof that an interaction exists. Two substances can be named together in a paper that never tested them in combination, and a source listed as background may cover only one of them.
Findings are quoted from each abstract as the authors wrote them. NutriStack has not re-analysed, pooled, or reconciled them, and they may disagree with each other.
NutriStack’s own interaction assessment for this pair is not published here. It has not completed qualified-human clinical review, so it is withheld from search. See the publication gate.
Nothing here is medical advice. Decisions about prescription medication and supplements belong with your prescriber or pharmacist, who can see your full regimen.

The research

7 studies naming Clopidogrel and Fish Oil.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Increased bruising with the combination of long-chain omega-3 fatty acids, flaxseed oil and clopidogrel.

Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC · 2013 · PMID 23795184

Case Reports

Names both Clopidogrel and Fish Oil in its title.

Polyunsaturated omega-3 fatty acids improve responsiveness to clopidogrel after percutaneous coronary intervention in patients with cytochrome P450 2C19 loss-of-function polymorphism.

Kardiologia polska · 2012 · PMID 22623230

Randomized Controlled Trial

“The addition of omega-3 ethyl esters significantly potentiates platelet response to clopidogrel after PCI mostly in patients with CYP2C19 loss-of-function polymorphism.”
Gajos et al. · Authors' conclusion

Names both Clopidogrel and Fish Oil in its title.

Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: beyond aspirin and clopidogrel.

Thrombosis research · 2011 · PMID 21621252

Clinical Trial30 participants

“In this pilot study we were able to successfully measure platelet surface charge variation as a measure of omega-3 PUFA effect on platelets. Our results suggest that omega-3 PUFA increase the total platelet surface charge and, therefore, attenuate platelet activation, even among patients taking aspirin or aspirin plus clopidogrel. Further studies are needed to determine the clinical significance of these measured effects and EQELS results.”
Cohen et al. · Authors' conclusion

Names both Clopidogrel and Fish Oil in its title.

Comparison of bleeding complications with omega-3 fatty acids + aspirin + clopidogrel--versus--aspirin + clopidogrel in patients with cardiovascular disease.

The American journal of cardiology · 2009 · PMID 19801023

Comparative StudyHuman subjects182 participants

“More patients had minor bleeding complications in the control group than in the treatment group; however, the difference was not statistically significant (p = 0.5). In conclusion, high-dose fish oil is safe in combination with aspirin and clopidogrel and does not increase the risk of bleeding compared with that seen with aspirin and clopidogrel alone.”
Watson et al. · From the abstract

Names both Clopidogrel and Fish Oil in its title.

Omega-3 Fatty Acid Ethyl Esters do not Improve Clopidogrel Associated P2Y12 Inhibition in Stroke Patients.

Neurology international · 2015 · PMID 26294943

Names both Clopidogrel and Fish Oil in its title.

Omega-3--clopidogrel can help!

Kardiologia polska · 2012 · PMID 22623231

CommentHuman subjects

Names both Clopidogrel and Fish Oil in its title.

Ask the doctor. Since having a heart attack, I have been taking lisinopril, Zocor, Plavix, aspirin, a multivitamin, fish oil, calcium, vitamin D, coenzyme Q(10), chia oil, B-50 complex, grape seed extract, Nu-Zymes, Natural Energy supplement, Super C22 and astragalus. I am thinking of taking a brain booster called Procera AVH. Will it interfere with my heart medications?

Harvard heart letter : from Harvard Medical School · 2009 · PMID 19685568

Human subjects

Names both Clopidogrel and Fish Oil in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

Selection. These records were found by searching PubMed titles and abstracts for both substance names alongside interaction and pharmacokinetic terms. Relevant work that phrases things differently, or is not indexed in PubMed, will be missing.
No effect size. The quoted conclusions are the authors’ words about their own study. We have not extracted effect direction or magnitude, and a single study’s conclusion is not a consensus.
Population mismatch. Findings in healthy volunteers, animals, or a specific patient group may not transfer to you, your dose, or your formulation.
Absence is not safety. Few published studies means the combination is under-studied, which is not the same as established as safe.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Clopidogrel, Fish Oil, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

Get NutriStack free → Read the methodology

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.