NutriStack
Fish Oil and Vitamin D3, a synergy.
Vitamin D3 is fat-soluble and absorption improves when taken with omega-3 fatty acids. Both support cardiovascular and immune health.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Fish Oil and Vitamin D3
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 3 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Vitamin D3 is fat-soluble and absorption improves when taken with omega-3 fatty acids. Both support cardiovascular and immune health.
Mechanism. D3 requires fat for micellar solubilization and absorption. Omega-3 fatty acids provide the lipid vehicle and share anti-inflammatory pathways via resolvin production.
Recommendation. Take D3 with fish oil or a meal containing fat for optimal absorption.
Sources (3)
- Dawson-Hughes B et al. Dietary fat increases vitamin D-3 absorption. J Acad Nutr Diet. 2015
- Uchida Y, Tsuji K, Ochi E. Effects of Omega-3 fatty acids supplementation and resistance training on skeletal muscle.. Clinical Nutrition ESPEN. 2024. PMID 38777432
- Chang MC, Choo YJ. Effects of Whey Protein, Leucine, and Vitamin D Supplementation in Patients with Sarcopenia: A Systematic Review and Meta-Analysis.. Nutrients. 2023. PMID 36771225
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fish Oil and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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