NutriStack
Dexamethasone and Vitamin D3, a synergy.
Dexamethasone rapidly depletes vitamin D stores through CYP24A1 induction. Supplementation is essential.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Dexamethasone and Vitamin D3
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 4 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Dexamethasone rapidly depletes vitamin D stores through CYP24A1 induction. Supplementation is essential.
Mechanism. Dexamethasone is the strongest CYP24A1 inducer among glucocorticoids, accelerating vitamin D degradation.
Recommendation. Supplement 1000-2000 IU D3 daily during dexamethasone therapy.
Sources (4)
- Buckley L et al. ACR guideline for glucocorticoid-induced osteoporosis. Arthritis Care Res. 2017;69(8):1095-1110. PMID 28585410
- Zhang Y, Fang F, Tang J et al.. Association between vitamin D supplementation and mortality: systematic review and meta-analysis.. BMJ. 2019. PMID 31405892
- Chang MC, Choo YJ. Effects of Whey Protein, Leucine, and Vitamin D Supplementation in Patients with Sarcopenia: A Systematic Review and Meta-Analysis.. Nutrients. 2023. PMID 36771225
- Fiamenghi VI, Mello ED. Vitamin D deficiency in children and adolescents with obesity: a meta-analysis.. Jornal de pediatria. 2021. PMID 33022267
Stack Score
How this pair moves the number.
Effect on the composite score
If both Dexamethasone and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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