NutriStack
Fish Oil and Vitamin E, a caution.
High-dose fish oil increases vitamin E requirements because PUFAs are susceptible to peroxidation. May deplete vitamin E stores.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution, Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. High-dose fish oil increases vitamin E requirements because PUFAs are susceptible to peroxidation. May deplete vitamin E stores.
Mechanism. EPA and DHA's multiple double bonds make them highly susceptible to lipid peroxidation. Each peroxidation event consumes one molecule of alpha-tocopherol, increasing turnover.
Recommendation. If taking high-dose fish oil (>3g/day), ensure adequate vitamin E intake to prevent PUFA-induced vitamin E depletion.
Sources (3)
- Meydani M. Vitamin E requirement in relation to dietary fish oil and oxidative stress. World Rev Nutr Diet. 1994
- Uchida Y, Tsuji K, Ochi E. Effects of Omega-3 fatty acids supplementation and resistance training on skeletal muscle.. Clinical Nutrition ESPEN. 2024. PMID 38777432
- Bayu P, Wibisono JJ. Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: A systematic review and meta-analysis of randomized controlled trials. PLoS One. 2024. PMID 38820340
Synergy · Strong evidence
Synergy
What is happening. Vitamin E protects omega-3 fatty acids from lipid peroxidation. High-dose fish oil may increase vitamin E requirements.
Mechanism. PUFAs (EPA/DHA) are highly susceptible to peroxidation due to multiple double bonds. Alpha-tocopherol intercepts lipid peroxyl radicals in membranes, preventing chain propagation.
Recommendation. Take vitamin E with fish oil to prevent PUFA oxidation. Many quality fish oil supplements include vitamin E for this reason.
Sources (3)
- Meydani M. Omega-3 fatty acids alter soluble markers of endothelial function in coronary heart disease patients. Nutr Rev. 2000
- Bayu P, Wibisono JJ. Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: A systematic review and meta-analysis of randomized controlled trials. PLoS One. 2024. PMID 38820340
- Uchida Y, Tsuji K, Ochi E. Effects of Omega-3 fatty acids supplementation and resistance training on skeletal muscle.. Clinical Nutrition ESPEN. 2024. PMID 38777432
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fish Oil and Vitamin E are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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