From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionModerate evidence
What is happening. Combining tocotrienols with high-dose vitamin E can increase total vitamin E exposure and bleeding risk.
Mechanism. Additive vitamin E anticoagulant and platelet effects.
Recommendation. Avoid high-dose duplicate vitamin E unless clinician-directed.
Stack Score
How it moves the number.
Effect on the composite score
If both Tocotrienols and Vitamin E are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Sen CK et al. Tocotrienols: Vitamin E Beyond Tocopherols. Life Sci. 2006.Needs sourceNo link