Supplement × Supplement·a caution·Moderate evidence

Tocotrienols + Vitamin E

Caution Moderate evidence

Combining tocotrienols with high-dose vitamin E can increase total vitamin E exposure and bleeding risk.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Caution
Evidence
Moderate
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionModerate evidence

What is happening. Combining tocotrienols with high-dose vitamin E can increase total vitamin E exposure and bleeding risk.

Mechanism. Additive vitamin E anticoagulant and platelet effects.

Recommendation. Avoid high-dose duplicate vitamin E unless clinician-directed.

Stack Score

How it moves the number.

Effect on the composite score

If both Tocotrienols and Vitamin E are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Sen CK et al. Tocotrienols: Vitamin E Beyond Tocopherols. Life Sci. 2006.Needs sourceNo link

Check your full routine

One pair was the worked example.

Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.