NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Coenzyme Q10 Ubiquinol and Vitamin E: what the published research says

PubMed indexes 8 records that name Coenzyme Q10 Ubiquinol and Vitamin E together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Coenzyme Q10 Ubiquinol and Vitamin E. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Coenzyme Q10 Ubiquinol and Vitamin E.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

The mode of action of lipid-soluble antioxidants in biological membranes. Relationship between the effects of ubiquinol and vitamin E as inhibitors of lipid peroxidation in submitochondrial particles.

Journal of nutritional science and vitaminology · 1992 · PMID 1297809

Comparative StudyReviewHuman subjects

“It is pointed out that ubiquinol is the only known lipid-soluble antioxidant that can be synthesized de novo in animal cells, and for which there exists an enzymic mechanism--the mitochondrial electron-transport system--that can regenerate the antioxidant from its oxidized form resulting from its inhibitory effect on lipid peroxidation.”

Ernster et al. · From the abstract

Names both Coenzyme Q10 Ubiquinol and Vitamin E in its title.

Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.

Proceedings of the National Academy of Sciences of the United States of America · 1991 · PMID 2000375

Comparative StudyHuman subjects

“LDL oxidation was reduced significantly by supplementing the lipoprotein preparation with physiological amounts of either ascorbate or ubiquinol-10. Our data show that ubiquinol-10 is much more efficient in inhibiting LDL oxidation than either lycopene, beta-carotene, or alpha-tocopherol.”

Stocker et al. · From the abstract

Names both Coenzyme Q10 Ubiquinol and Vitamin E in its title.

Synthesis and controlled drug delivery studies of a novel Ubiquinol-Polyethylene glycol-Vitamin E adduct.

Bioorganic chemistry · 2020 · PMID 33068813

Human subjects

“The antioxidant activity evaluation was carried out by DPPH assay. Our results indicated that the chemical modification after esterification with PEG of the two drugs Ubiquinol and Vitamin E doesn't significantly affected their antioxidant potential.”

Cateni et al. · From the abstract

Names both Coenzyme Q10 Ubiquinol and Vitamin E in its title.

Ubiquinol prevents alpha-tocopherol consumption during liposome peroxidation.

Biochemistry international · 1991 · PMID 1872885

“Rates of conjugated diene formation and concomitant disappearance of the two antioxidants was measured. Since the inhibition rate constant for the scavenging of peroxyl radical for alpha-tocopherol was higher than that for quinol-3, it was concluded that alpha-tocopherol is regenerated by ubiquinol-3.”

Cabrini et al. · From the abstract

Names both Coenzyme Q10 Ubiquinol and Vitamin E in its title.

Ubiquinol improves symptoms in children with autism.

Oxidative medicine and cellular longevity · 2014 · PMID 24707344

Clinical Trial

“Beneficial effect of ubiquinol in children with autism has been demonstrated for the first time. We assume that plasma concentration of CoQ10-TOTAL and lipid peroxidation could be used as relevant biomarkers of ubiquinol supportive therapy.”

Gvozdjáková et al. · Authors' conclusion

Names Coenzyme Q10 Ubiquinol and Vitamin E together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Coenzyme Q10 Ubiquinol, Vitamin E, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.