NutriStack
Vitamin E and Vitamin K2, a caution.
High-dose vitamin E may reduce K2-dependent protein carboxylation, potentially affecting both bone and cardiovascular K2 benefits.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Vitamin E and Vitamin K2
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. High-dose vitamin E may reduce K2-dependent protein carboxylation, potentially affecting both bone and cardiovascular K2 benefits.
Mechanism. Excess alpha-tocopherol competitively inhibits GGCX enzyme activity needed for K2-dependent carboxylation of osteocalcin and matrix GLA protein.
Recommendation. Keep vitamin E at moderate doses (200 IU or less) when relying on K2 for bone and cardiovascular health.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Vitamin E and Vitamin K2 are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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