NutriStack
Fish Oil and Rosuvastatin, a synergy.
Fish oil omega-3 fatty acids can be used with rosuvastatin for residual hypertriglyceridemia. Human pharmacokinetic studies found no clinically important interaction between omega-3 fatty acid products and rosuvastatin. The expected benefit is triglyceride lowering, not extra LDL lowering.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Fish Oil and Rosuvastatin
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Fish oil omega-3 fatty acids can be used with rosuvastatin for residual hypertriglyceridemia. Human pharmacokinetic studies found no clinically important interaction between omega-3 fatty acid products and rosuvastatin. The expected benefit is triglyceride lowering, not extra LDL lowering.
Mechanism. Rosuvastatin lowers LDL through HMG-CoA reductase inhibition, while omega-3 fatty acids reduce hepatic VLDL-triglyceride synthesis. Phase I studies found rosuvastatin exposure remained within no-interaction bounds when coadministered with omega-3 products.
Recommendation. Consider fish oil with rosuvastatin if triglycerides remain elevated and you can use a reliable, consistent product. Recheck fasting lipids after starting because LDL cholesterol can respond differently depending on the omega-3 formulation.
Sources (2)
- Gosai P, Liu J, Doyle RT, Johnson J, Carter R, Sica D, et al. Effect of omega-3-acid ethyl esters on the steady-state plasma pharmacokinetics of rosuvastatin in healthy adults. Expert Opin Pharmacother. 2008;9(17):2947-2953. PMID 19006471
- Offman E, Davidson M, Nilsson C. Assessment of pharmacokinetic interaction between omega-3 carboxylic acids and the statins rosuvastatin and simvastatin: Results of 2 phase I studies in healthy volunteers. J Clin Lipidol. 2017;11(3):739-748. PMID 28506390
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fish Oil and Rosuvastatin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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