NutriStack
Coenzyme Q10 and Rosuvastatin, a synergy.
Statins inhibit HMG-CoA reductase, which is also upstream of CoQ10 synthesis in the mevalonate pathway. Rosuvastatin can reduce plasma CoQ10 by 40%. CoQ10 supplementation may alleviate statin-associated myalgia.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Coenzyme Q10 and Rosuvastatin
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 6 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Statins inhibit HMG-CoA reductase, which is also upstream of CoQ10 synthesis in the mevalonate pathway. Rosuvastatin can reduce plasma CoQ10 by 40%. CoQ10 supplementation may alleviate statin-associated myalgia.
Mechanism. HMG-CoA reductase inhibition blocks mevalonate production, reducing both cholesterol and CoQ10 synthesis. CoQ10 is essential for mitochondrial electron transport chain function in muscle.
Recommendation. Consider CoQ10 100-200mg/day if experiencing muscle symptoms on rosuvastatin. CoQ10 does not interfere with rosuvastatin's cholesterol-lowering effect.
Sources (6)
- Qu H, Guo M, Chai H, Wang WT, Gao ZY, Shi DZ. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2018;7(19):e009835. PMID 30371340
- Kang Y, Park JM, Lee SH. Moderate-Intensity Rosuvastatin/Ezetimibe Combination versus Quadruple-Dose Rosuvastatin Monotherapy: A Meta-Analysis and Systemic Review. Yonsei Medical Journal. 2024. PMID 38154476
- Tsai IC, Hsu CW, Chang CH et al.. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. Frontiers in Pharmacology. 2022. PMID 36091835
- Liu Z, Tian Z, Zhao D et al.. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.. Journal of Clinical Endocrinology and Metabolism. 2022. PMID 36337001
- Hou S, Tian Z, Zhao D et al.. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.. Molecular Nutrition & Food Research. 2023. PMID 37118903
- Sazali S, Badrin S, Norhayati MN et al.. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis.. BMJ Open. 2021. PMID 33402403
Stack Score
How this pair moves the number.
Effect on the composite score
If both Coenzyme Q10 and Rosuvastatin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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