NSTK · 01.2026Independent supplement reference
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Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Coenzyme Q10 and Rosuvastatin: what the published research says

PubMed indexes 8 records that name Coenzyme Q10 and Rosuvastatin together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Coenzyme Q10 and Rosuvastatin. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Coenzyme Q10 and Rosuvastatin.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease.

Atherosclerosis · 2011 · PMID 21458815

Randomized Controlled Trial

“Compared to atorvastatin, rosuvastatin combined with exercise significantly preserved ubiquinol levels associated with an increase in HDL-C. Rosuvastatin with regular exercise could be beneficial for CAD patients.”

Toyama et al. · Authors' conclusion

Names both Coenzyme Q10 and Rosuvastatin in its title.

Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure).

Journal of the American College of Cardiology · 2010 · PMID 20883926

Comparative StudyControlled Clinical TrialMulticenter StudyRandomized Controlled Trial

“Coenzyme Q₁₀ is not an independent prognostic variable in heart failure. Rosuvastatin reduced coenzyme Q₁₀, but even in patients with a low baseline coenzyme Q₁₀, rosuvastatin treatment was not associated with a significantly worse outcome. (Controlled Rosuvastatin Multinational Study in Heart Failure [CORONA]; NCT00206310).”

McMurray et al. · Authors' conclusion

Names both Coenzyme Q10 and Rosuvastatin in its title.

CoQ10 Augments Rosuvastatin Neuroprotective Effect in a Model of Global Ischemia via Inhibition of NF-κB/JNK3/Bax and Activation of Akt/FOXO3A/Bim Cues.

Frontiers in pharmacology · 2017 · PMID 29081748

“Together, these findings accentuate the neuroprotective potentials of both treatments against global I/R by virtue of their rigorous multi-pronged actions, including suppression of hippocampal oxidative stress, inflammation, and apoptosis with the involvement of the Akt/FOXO3A/Bim and JNK3/c-Jun/Bax signaling pathways. The study also nominates CoQ10 as an adds-on therapy with statins.”

Abd El-Aal et al. · From the abstract

Names both Coenzyme Q10 and Rosuvastatin in its title.

Targeting proinflammatory cytokines, oxidative stress, TGF-β1 and STAT-3 by rosuvastatin and ubiquinone to ameliorate trastuzumab cardiotoxicity.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017 · PMID 28622591

Animal study

“These changes were significant in rosuvastatin/ubiquinone combination group compared to the use of each of these drugs alone. In conclusion, rosuvastatin/ubiquinone combination may represent a new therapeutic modality to ameliorate TRZ-induced cardiotoxicity.”

Kabel et al. · From the abstract

Names both Coenzyme Q10 and Rosuvastatin in its title.

Rosuvastatin lowers coenzyme Q10 levels, but not mitochondrial adenosine triphosphate synthesis, in children with familial hypercholesterolemia.

The Journal of pediatrics · 2011 · PMID 20884007

Human subjects

“In children with FH, rosuvastatin causes a significant decrease in cellular PBMC CoQ10 status but does not affect mitochondrial adenosine triphosphate synthesis in children with FH. Further studies should address whether (rare) side effects of statin therapy could be explained by a deterioration in CoQ10 status.”

Avis et al. · Authors' conclusion

Names both Coenzyme Q10 and Rosuvastatin in its title.

Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia.

The American journal of cardiology · 2012 · PMID 22112743

Comparative StudyRandomized Controlled Trial

“Coadministration of ezetimibe and granulated colestimide further lowered serum LDL cholesterol more than rosuvastatin alone without changing plasma coenzyme Q10 and proprotein convertase subtilisin/kexin type 9 levels. In conclusion, adequate introduction of this aggressive cholesterol-lowering regimen can improve the lipid profile of FH.”

Kawashiri et al. · From the abstract

Names Coenzyme Q10 and Rosuvastatin together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Coenzyme Q10, Rosuvastatin, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.