NutriStack
Coenzyme Q10 and Vitamin B2, a synergy.
Riboflavin and coenzyme Q10 both support mitochondrial energy production and are used together for migraine prophylaxis, where their effects on the electron transport chain are complementary.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Coenzyme Q10 and Vitamin B2
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Riboflavin and coenzyme Q10 both support mitochondrial energy production and are used together for migraine prophylaxis, where their effects on the electron transport chain are complementary.
Mechanism. Riboflavin-derived FAD and FMN serve as electron carriers at Complexes I and II, while coenzyme Q10 shuttles those electrons onward to Complex III, so the two act at adjacent steps of the same respiratory chain.
Recommendation. Reasonable to combine for migraine prevention or mitochondrial support. Common research dosing is riboflavin 400mg daily with CoQ10 around 100mg to 300mg daily.
Sources (2)
- Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomized controlled trial. Neurology. 1998
- Sandor PS et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology. 2005
Stack Score
How this pair moves the number.
Effect on the composite score
If both Coenzyme Q10 and Vitamin B2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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