What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Celecoxib + Fish Oil pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Celecoxib and Fish Oil, a caution.

Q: Can I take Celecoxib and Fish Oil together?

Possibly, but with caution. Celecoxib and Fish Oil have a documented caution-tier interaction. Fish oil has mild antiplatelet effects and may add bleeding risk to celecoxib in higher-risk situations. Modern randomized-trial evidence suggests usual omega-3 doses do not greatly increase bleeding, but high-dose EPA/DHA or combination with aspirin can matter. The risk is most relevant around procedures or in people with prior GI bleeding.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Fish oil has mild antiplatelet effects and may add bleeding risk to celecoxib in higher-risk situations. Modern randomized-trial evidence suggests usual omega-3 doses do not greatly increase bleeding, but high-dose EPA/DHA or combination with aspirin can matter. The risk is most relevant around procedures or in people with prior GI bleeding.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Celecoxib and Fish Oil
Pair type: Caution
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Moderate evidence

Caution

What is happening. Fish oil has mild antiplatelet effects and may add bleeding risk to celecoxib in higher-risk situations. Modern randomized-trial evidence suggests usual omega-3 doses do not greatly increase bleeding, but high-dose EPA/DHA or combination with aspirin can matter. The risk is most relevant around procedures or in people with prior GI bleeding.

Mechanism. EPA and DHA can reduce platelet aggregation and thromboxane A2 production, although clinical bleeding effects are usually small at standard doses. Celecoxib can still cause GI injury, particularly with aspirin or other risk factors.

Recommendation. Use caution with high-dose fish oil while taking celecoxib, especially if you also take aspirin. Pause fish oil before procedures if your clinical team requests it, and report black stools, vomiting blood, or unusual bruising.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Celecoxib and Fish Oil are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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