NutriStack
Alcohol and Celecoxib, a caution.
Celecoxib generally causes fewer upper GI ulcers than many nonselective NSAIDs, but alcohol can still increase GI irritation and bleeding risk. The risk becomes more clinically important with higher celecoxib doses, prior ulcer disease, older age, or combined aspirin use. Alcohol also worsens dehydration, which can increase NSAID kidney risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Celecoxib generally causes fewer upper GI ulcers than many nonselective NSAIDs, but alcohol can still increase GI irritation and bleeding risk. The risk becomes more clinically important with higher celecoxib doses, prior ulcer disease, older age, or combined aspirin use. Alcohol also worsens dehydration, which can increase NSAID kidney risk.
Mechanism. Celecoxib selectively inhibits COX-2, but GI protection is not complete, especially at higher doses or with aspirin. Alcohol causes direct gastric mucosal irritation and can worsen volume depletion, adding to NSAID-related GI and renal stress.
Recommendation. Avoid heavy alcohol use while taking celecoxib. If you have ulcer history or take low-dose aspirin with celecoxib, ask your clinician whether you need a stomach-protection strategy.
Sources (2)
- Sostres C, Gargallo CJ, Arroyo MT, Lanas A. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2010;24(2):121-132. PMID 20227026
- Strate LL, Singh P, Boylan MR, Piawah S, Cao Y, Chan AT. A Prospective Study of Alcohol Consumption and Smoking and the Risk of Major Gastrointestinal Bleeding in Men. PLoS One. 2016;11(11):e0165278. PMID 27824864
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and Celecoxib are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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