NutriStack
Alcohol and Cannabis (THC-Dominant), a conflict.
Combining THC-dominant cannabis with alcohol produces additive central nervous system depression and impairment, with greater sedation, dizziness, nausea, and markedly worse psychomotor and driving performance than either alone.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alcohol and Cannabis (THC-Dominant)
- Pair type
- Conflict
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −10 to your Stack Score (per scored conflict row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Conflict · Strong evidence
Conflict
What is happening. Combining THC-dominant cannabis with alcohol produces additive central nervous system depression and impairment, with greater sedation, dizziness, nausea, and markedly worse psychomotor and driving performance than either alone.
Mechanism. Alcohol can increase THC absorption and both act as CNS depressants, producing additive impairment of cognition, coordination, and reaction time along with cardiovascular and gastrointestinal effects.
Recommendation. Do not combine. The mix sharply increases impairment and accident risk; do not drive or operate machinery, and seek medical advice if severe vomiting, confusion, or loss of consciousness occurs.
Sources (2)
- Hartman RL et al. Controlled Cannabis Vaporizer Administration: Blood and Plasma Cannabinoids with and without Alcohol. Clin Chem. 2015;61(6):850-69. PMID 26019183
- Downey LA et al. The effects of cannabis and alcohol on simulated driving: Influences of dose and experience. Accid Anal Prev. 2013;50:879-86. PMID 22871272
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and Cannabis (THC-Dominant) are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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