NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Alcohol and Cannabis (THC-Dominant): what the published research says

PubMed indexes 8 records that name Alcohol and Cannabis (THC-Dominant) together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Alcohol and Cannabis (THC-Dominant). It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Alcohol and Cannabis (THC-Dominant).

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Cannabis and alcohol--a close friendship.

Trends in pharmacological sciences · 2003 · PMID 12823949

Comparative StudyReviewAnimal study

“Indeed, both cannabinoids and alcohol cause the release of dopamine in the nucleus accumbens. Recent research suggests that ethanol preference, which is dependent on CB(1) receptors, is higher in young mice than in old mice, and higher in female mice than in male mice.”

Mechoulam et al. · From the abstract

Names both Alcohol and Cannabis (THC-Dominant) in its title.

Sexual behaviors, cannabis, alcohol and monkeypox infection.

Frontiers in public health · 2023 · PMID 36733281

ReviewHuman subjects

“Thus, cannabis use and alcohol consumption may have two detrimental effects on the MPXV outbreak: by participating in the increase of the number of sexual partners which are mainly responsible for the augmentation of the number of new MPXV infected cases and by impairing the immune response to a viral infection.”

Vallée · From the abstract

Names both Alcohol and Cannabis (THC-Dominant) in its title.

Combined exposure to alcohol and cannabis during development: Mechanisms and outcomes.

Alcohol (Fayetteville, N.Y.) · 2023 · PMID 36740025

ReviewResearch Support, N.I.H., ExtramuralHuman subjects

“These interactions can be synergistic and exacerbate the deleterious consequences of developmental alcohol exposure. The present review focuses on interactions between alcohol and cannabis exposure and the potential consequences of these interactions.”

Kovács et al. · From the abstract

Names both Alcohol and Cannabis (THC-Dominant) in its title.

Alcohol and Cannabis Use Disorders.

The American journal of psychiatry · 2022 · PMID 34974757

EditorialIntroductory Journal ArticleHuman subjects

Names both Alcohol and Cannabis (THC-Dominant) in its title.

Patterns of Cannabis and Alcohol Co-Use: Substitution Versus Complementary Effects.

Alcohol research : current reviews · 2022 · PMID 35223338

Research Support, N.I.H., ExtramuralReviewHuman subjects

“Results of this review reveal compelling evidence for both substitution and complementary effects, suggesting nuanced yet significant distinctions across different populations examined in these studies. Several mechanisms for the impact of cannabis use on alcohol-related outcomes are identified, including patterns and context of co-use, timing and order of use, cannabinoid formulation, pharmacokinetic interactions, and user characteristics (including diagnostic status), all…”

Gunn et al. · Authors' conclusion

Names both Alcohol and Cannabis (THC-Dominant) in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Cannabis (THC-Dominant), and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.