NutriStack
Alcohol and Cocaine, contraindicated.
Combining cocaine with alcohol produces cocaethylene in the liver, a longer-lasting and more cardiotoxic compound that sharply increases the risk of heart attack, arrhythmia, and sudden death.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. Combining cocaine with alcohol produces cocaethylene in the liver, a longer-lasting and more cardiotoxic compound that sharply increases the risk of heart attack, arrhythmia, and sudden death.
Mechanism. Hepatic transesterification of cocaine in the presence of ethanol forms cocaethylene, which has a longer half-life than cocaine and potently blocks dopamine reuptake while exerting greater cardiotoxicity and additive sympathetic stimulation.
Recommendation. Do not combine. This is a dangerous combination associated with sudden cardiac death. If experiencing chest pain, severe agitation, or breathing difficulty, seek emergency medical care immediately.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and Cocaine are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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