NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Alcohol and Cetirizine: what the published research says

PubMed indexes 8 records that name Alcohol and Cetirizine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Alcohol and Cetirizine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Alcohol and Cetirizine.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Psychomotor and subjective effects of bilastine, hydroxyzine, and cetirizine, in combination with alcohol: a randomized, double-blind, crossover, and positive-controlled and placebo-controlled Phase I clinical trials.

Human psychopharmacology · 2014 · PMID 24395298

Clinical Trial, Phase IRandomized Controlled Trial

“Concomitant administration of bilastine (at therapeutic dose) and alcohol does not produce greater central nervous system depressant effects than ACL alone.”

García-Gea et al. · Authors' conclusion

Names both Alcohol and Cetirizine in its title.

Evaluation of the cognitive, psychomotor and pharmacokinetic profiles of rupatadine, hydroxyzine and cetirizine, in combination with alcohol, in healthy volunteers.

Human psychopharmacology · 2006 · PMID 16389668

Comparative StudyRandomized Controlled Trial

“Present results showed that single oral doses of rupatadine 10 mg in combination with alcohol do not produce more cognitive and psychomotor impairment than alcohol alone. Higher doses of rupatadine, in combination with alcohol, may induce cognitive and psychomotor deterioration as hydroxyzine and cetirizine at therapeutic doses.”

Barbanoj et al. · Authors' conclusion

Names both Alcohol and Cetirizine in its title.

Lack of potentiation by cetirizine of alcohol-induced psychomotor disturbances.

European journal of clinical pharmacology · 1988 · PMID 2971550

Clinical TrialControlled Clinical Trial

“There was no adverse interaction between cetirizine 2 HCl and alcohol. Cetirizine and alcohol did not modify each others blood levels.”

Doms et al. · From the abstract

Names both Alcohol and Cetirizine in its title.

Second generation H1 - antihistamines interaction with food and alcohol-A systematic review.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017 · PMID 28622592

Systematic ReviewHuman subjects

“For selected H1-antihistamines food, fruit juices or alcohol consumption may significantly impact the efficacy and safety of the therapy. This issue shall be well understood to educate patients properly, as it provides the major therapeutic element in allergic diseases.”

Paśko et al. · From the abstract

Names Alcohol and Cetirizine together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Cetirizine, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.