NutriStack
Alcohol and Baclofen, a caution.
Alcohol and baclofen can both cause sedation, dizziness, slowed reaction time, and impaired coordination. Human alcohol-challenge studies show baclofen can increase sedation and impair performance, and higher baclofen plus alcohol exposure has been associated with major sedation. This is especially risky for driving, falls, and accidental overdose.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Alcohol and baclofen can both cause sedation, dizziness, slowed reaction time, and impaired coordination. Human alcohol-challenge studies show baclofen can increase sedation and impair performance, and higher baclofen plus alcohol exposure has been associated with major sedation. This is especially risky for driving, falls, and accidental overdose.
Mechanism. Baclofen is a GABA-B receptor agonist that reduces excitatory neurotransmission in the spinal cord and brain. Alcohol also enhances inhibitory signaling and impairs cortical and cerebellar function, producing additive sedation and psychomotor impairment.
Recommendation. Avoid alcohol while taking baclofen unless your prescriber is deliberately supervising baclofen for alcohol use disorder. Do not drive or operate machinery if you have used both. Report heavy sedation, confusion, fainting, or breathing problems promptly.
Sources (2)
- Evans SM, Bisaga A. Acute interaction of baclofen in combination with alcohol in heavy social drinkers. Alcohol Clin Exp Res. 2009;33(1):19-30. PMID 18840257
- Rolland B, Labreuche J, Duhamel A, Deheul S, Gautier S, Auffret M, et al. Baclofen for alcohol dependence: Relationships between baclofen and alcohol dosing and the occurrence of major sedation. Eur Neuropsychopharmacol. 2015;25(10):1631-1636. PMID 26095229
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and Baclofen are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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