NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Acitretin and Alcohol: what the published research says

PubMed indexes 6 records that name Acitretin and Alcohol together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Acitretin and Alcohol. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

6 studies naming Acitretin and Alcohol.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Acitretin is converted to etretinate only during concomitant alcohol intake.

The British journal of dermatology · 2000 · PMID 11122016

Human subjects20 participants

“Owing to the teratogenic potential and possible side-effects of oral retinoids, fertile women especially should be informed about the importance of strict alcohol abstinence during treatment and for at least 2 months after stopping therapy. In case of non-compliance with alcohol abstinence a post-therapy contraceptive period of 2-3 years should be recommended.”

Grønhøj Larsen et al. · Authors' conclusion

Names both Acitretin and Alcohol in its title.

Conversion of acitretin to etretinate in psoriatic patients is influenced by ethanol.

The Journal of investigative dermatology · 1993 · PMID 8491984

Human subjects

“The risk of metabolic formation of etretinate in acitretin recipients makes it impossible to draw any definite conclusion with regard to recommendation of length of anticonceptive period following acitretin therapy in psoriatics. Monitoring of plasma etretinate levels in acitretin-treated fertile women is advisable.”

Larsen et al. · From the abstract

Names both Acitretin and Alcohol in its title.

Percutaneous absorption of retinoids: influence of vehicle, light exposure, and dose.

The Journal of investigative dermatology · 1988 · PMID 3385216

Comparative StudyHuman subjects

“In accord with this result, the amount of isotretinoin and acitretin which penetrated epidermis did not increase in proportion to dose over a 25-fold range of dose in human skin. Dermal concentration at doses of 10 micrograms/cm2 of isotretinoin and acitretin were greater than that reported for shave biopsies of human skin following treatment for several months with clinically effective doses of isotretinoin and etretinate (the parent ester of the acid acitretin).”

Lehman et al. · From the abstract

Names Acitretin and Alcohol together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Acitretin, Alcohol, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.