NutriStack
Alcohol and Cyclobenzaprine, a caution.
Cyclobenzaprine commonly causes drowsiness, dizziness, and slowed reaction time, and alcohol can intensify those effects. Combining them can increase falls, accidents, impaired driving, confusion, and overdose risk. Older adults are especially vulnerable because skeletal muscle relaxants are poorly tolerated in that group.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alcohol and Cyclobenzaprine
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Cyclobenzaprine commonly causes drowsiness, dizziness, and slowed reaction time, and alcohol can intensify those effects. Combining them can increase falls, accidents, impaired driving, confusion, and overdose risk. Older adults are especially vulnerable because skeletal muscle relaxants are poorly tolerated in that group.
Mechanism. Cyclobenzaprine is a centrally acting skeletal muscle relaxant with sedating and anticholinergic effects. Alcohol adds central nervous system depression and psychomotor impairment, increasing the net effect on alertness, balance, and reaction time.
Recommendation. Avoid alcohol while taking cyclobenzaprine. If alcohol was used, do not drive, operate tools, or take extra sedatives that day. Contact your prescriber if you need muscle spasm treatment but cannot reliably avoid alcohol.
Sources (2)
- Witenko C, Moorman-Li R, Motycka C, Duane K, Hincapie-Castillo J, Leonard P, et al. Considerations for the appropriate use of skeletal muscle relaxants for the management of acute low back pain. P T. 2014;39(6):427-435. PMID 25050056
- Elder NC. Abuse of skeletal muscle relaxants. Am Fam Physician. 1991;44(4):1223-1226. PMID 1927837
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and Cyclobenzaprine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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