NutriStack
Alcohol and Amphetamine/Dextroamphetamine, a caution.
Amphetamine/dextroamphetamine can partially counter alcohol-related psychomotor slowing without making the person sober. This can make intoxication feel less obvious and encourage more drinking, driving, risky activity, or additional stimulant use. Alcohol and stimulants can also add cardiovascular strain, especially with binge drinking or dehydration.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alcohol and Amphetamine/Dextroamphetamine
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Amphetamine/dextroamphetamine can partially counter alcohol-related psychomotor slowing without making the person sober. This can make intoxication feel less obvious and encourage more drinking, driving, risky activity, or additional stimulant use. Alcohol and stimulants can also add cardiovascular strain, especially with binge drinking or dehydration.
Mechanism. Dextroamphetamine increases catecholamine signaling and alertness, while ethanol impairs judgment, coordination, and reaction time through CNS depressant effects. The stimulant can mask perceived impairment without reversing alcohol's cognitive and motor risks, and both can increase cardiovascular workload.
Recommendation. Avoid alcohol on days you take amphetamine/dextroamphetamine when possible. If you drink, keep intake low, do not drive, and do not take extra stimulant doses to stay alert. Seek care for chest pain, fainting, severe agitation, confusion, or an irregular heartbeat.
Sources (2)
- Perez-Reyes M, White WR, McDonald SA, Hicks RE. Interaction between ethanol and dextroamphetamine: effects on psychomotor performance. Alcohol Clin Exp Res. 1992;16(1):75-81. PMID 1558306
- Althobaiti YS, Sari Y. Alcohol Interactions with Psychostimulants: An Overview of Animal and Human Studies. J Addict Res Ther. 2016;7(3):281. PMID 27478679
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and Amphetamine/Dextroamphetamine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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