NutriStack
Celecoxib and Resveratrol, a caution.
Resveratrol may increase celecoxib exposure and also has antiplatelet effects, creating a plausible safety concern. A human pharmacokinetic study found celecoxib disposition changed with resveratrol co-administration. The combination is most relevant with higher celecoxib doses, bleeding risk, cardiovascular risk, or other medicines affected by CYP pathways.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Celecoxib and Resveratrol
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Resveratrol may increase celecoxib exposure and also has antiplatelet effects, creating a plausible safety concern. A human pharmacokinetic study found celecoxib disposition changed with resveratrol co-administration. The combination is most relevant with higher celecoxib doses, bleeding risk, cardiovascular risk, or other medicines affected by CYP pathways.
Mechanism. Resveratrol can inhibit platelet activation and may alter celecoxib pharmacokinetics, likely through metabolic or transporter effects. Increased celecoxib exposure could increase NSAID-related renal, blood pressure, cardiovascular, or GI toxicity in susceptible users.
Recommendation. Use caution with resveratrol supplements while taking celecoxib, especially at high doses. Watch for celecoxib adverse effects such as stomach pain, edema, blood pressure worsening, bruising, or black stools.
Sources (2)
- Helal NI, El-Khodary NM, Omran GA, El-Masry SM. Effects of Resveratrol Co-Administration on Celecoxib Disposition and Pharmacokinetics in Healthy Volunteers. Drug Res (Stuttg). 2023;73(9):520-527. PMID 37935204
- Marumo M, Ekawa K, Wakabayashi I. Resveratrol inhibits Ca(2+) signals and aggregation of platelets. Environ Health Prev Med. 2020;25(1):70. PMID 33160329
Stack Score
How this pair moves the number.
Effect on the composite score
If both Celecoxib and Resveratrol are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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