NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Celecoxib and Resveratrol: what the published research says

PubMed indexes 4 records that name Celecoxib and Resveratrol together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Celecoxib and Resveratrol. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Celecoxib and Resveratrol.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test.

Life sciences · 2002 · PMID 11991254

Comparative StudyAnimal study

“Results indicate that the selective COX-2 inhibitor celecoxib does not produce peripheral antinociception in formalin-induced inflammatory pain. In contrast, selective COX-1 and non-selective COX inhibitors (resveratrol and diclofenac, respectively) are effective drugs in this model of pain.”

Torres-López et al. · From the abstract

Names both Celecoxib and Resveratrol in its title.

Effects of Resveratrol Co-Administration on Celecoxib Disposition and Pharmacokinetics in Healthy Volunteers.

Drug research · 2023 · PMID 37935204

Human subjects

“The obtained results suggested the presence of a beneficial pharmacokinetic interaction between RSV and celecoxib. Consequently, combining resveratrol as an herbal remedy and celecoxib as an anti-inflammatory drug may synergistically reduce inflammation and osteoarthritis with minimal side effects.”

Helal et al. · From the abstract

Names both Celecoxib and Resveratrol in its title.

Prediction of drug-drug plasma protein binding interactions of resveratrol in combination with celecoxib and leflunomide by molecular docking combined with an ultrafiltration technique.

Acta pharmaceutica (Zagreb, Croatia) · 2019 · PMID 36973944

“Molecular docking results have shown that resveratrol interacts with HSA mainly through hydrogen bond and π-π stacking, while celecoxib and leflunomide bind only with the hydrogen bond. Celecoxib or leflunomide, even at high tested doses, did not affect the plasma protein binding of resveratrol, thus suggesting pharmacological suitability of the investigated combinations.”

Zhou et al. · From the abstract

Names both Celecoxib and Resveratrol in its title.

Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2014 · PMID 25254309

Human subjects

“This study showed that in NMU-induced mammary cancer in rats, the combination of resveratrol and celecoxib led to a significant reduction in all tumor parameters. In addition, in terms of tumor volume, the combination was more efficient than celecoxib as a single agent.”

Kisková et al. · From the abstract

Names both Celecoxib and Resveratrol in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Celecoxib, Resveratrol, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.